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Early outcomes of thrombolysis for acute ischaemic stroke in a South African tertiary care centre
Includes abstract.
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
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Department of Medicine
2014
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| _version_ | 1867613814310043648 |
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| access_status_str | Open Access |
| author | Wasserman, Sean |
| author2 | Bryer, Alan |
| author_browse | Bryer, Alan Wasserman, Sean |
| author_facet | Bryer, Alan Wasserman, Sean |
| author_sort | Wasserman, Sean |
| collection | Thesis |
| description | Includes abstract. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/3493 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:42:07.673Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Department of Medicine |
| publisherStr | Department of Medicine |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/3493 Early outcomes of thrombolysis for acute ischaemic stroke in a South African tertiary care centre Wasserman, Sean Bryer, Alan Internal Medicine Includes abstract. Includes bibliographical references. Stroke is an important cause of death and disability in sub-Saharan Africa. Recombinant tissue plasminogen activator (tPA) thrombolysis is effective in treating acute ischaemic stroke, but may not be a viable option in developing countries. This prospective observational study was designed to assess the short-termoutcomes and safety of tPA for the treatment of stroke at Groote Schuur Hospital.Data was collected from January 2000 to February 2012, and included patients witha clinical diagnosis of acute stroke with onset of stroke symptoms within 4.5 hours ofreceiving thrombolysis. Exclusion criteria were based on the National Institute ofNeurological Disorders and Stroke (NINDS) rt-PA trial protocol (upper age limit was 75 years). Primary outcomes were the proportion of patients achieving significant early neurological recovery defined as an improvement of 4 or more points on the National Institutes of Health stroke scale (NIHSS) score and functional independence defined as a modified Rankin score of 2 or less at discharge. The primary safety measures were the rates of symptomatic intracranial haemorrhage (SICH) and death. From January 2000 to February 2011 42 patients were thrombolysed, with a mean time to tPA infusion of 160 minutes (standard deviation (SD) 50; range 60 - 270). By discharge the median NIHSS score fell from 14 (interquartile range (IQR) 10.5 - 17) to 7.5 (IQR 1 - 15); 28 (66.7%) achieved significant neurological improvement, and 17 (40.5%) were functionally independent. Two patients (4.8%) suffered SICH and there were 3 (7.1%) deaths. Thrombolysis in routine clinical practice in a South African setting has similar safety and early efficacy outcomes to controlled trials and open-label studies in developing and developed countries. 2014-07-29T09:16:43Z 2014-07-29T09:16:43Z 2012 Master Thesis Masters MMed http://hdl.handle.net/11427/3493 eng application/pdf Department of Medicine Faculty of Health Sciences University of Cape Town |
| spellingShingle | Internal Medicine Wasserman, Sean Early outcomes of thrombolysis for acute ischaemic stroke in a South African tertiary care centre |
| thesis_degree_str | Master's |
| title | Early outcomes of thrombolysis for acute ischaemic stroke in a South African tertiary care centre |
| title_full | Early outcomes of thrombolysis for acute ischaemic stroke in a South African tertiary care centre |
| title_fullStr | Early outcomes of thrombolysis for acute ischaemic stroke in a South African tertiary care centre |
| title_full_unstemmed | Early outcomes of thrombolysis for acute ischaemic stroke in a South African tertiary care centre |
| title_short | Early outcomes of thrombolysis for acute ischaemic stroke in a South African tertiary care centre |
| title_sort | early outcomes of thrombolysis for acute ischaemic stroke in a south african tertiary care centre |
| topic | Internal Medicine |
| url | http://hdl.handle.net/11427/3493 |
| work_keys_str_mv | AT wassermansean earlyoutcomesofthrombolysisforacuteischaemicstrokeinasouthafricantertiarycarecentre |