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Characterization of molecular and functional changes regulating hypobaric hypoxia-induced right ventricular hypertrophy
Includes bibliographical references.
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| Main Author: | |
|---|---|
| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Department of Medicine
2014
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| _version_ | 1867613224291008513 |
|---|---|
| access_status_str | Open Access |
| author | Zungu, Makhosazane |
| author2 | Essop, M Faadiel |
| author_browse | Essop, M Faadiel Zungu, Makhosazane |
| author_facet | Essop, M Faadiel Zungu, Makhosazane |
| author_sort | Zungu, Makhosazane |
| collection | Thesis |
| description | Includes bibliographical references. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/3498 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:32:44.899Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Department of Medicine |
| publisherStr | Department of Medicine |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/3498 Characterization of molecular and functional changes regulating hypobaric hypoxia-induced right ventricular hypertrophy Zungu, Makhosazane Essop, M Faadiel Medicine Includes bibliographical references. The major finding of this part of the study is that in vivo Wy-14,643 admnistration elicited direct effects on mitochondrial respiratory function and cardiac contractility. The data show that Wy-14,643 treatment attenuated mitochondrial respiration (state 3 respiration and rate of ADP phosphorylation) in the RV while promoting uncoupling of mitochondrial oxidative phosphorylation (increased state 4 respiration and basal leak) in the LV. 2014-07-29T09:38:49Z 2014-07-29T09:38:49Z 2007 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/3498 eng application/pdf Department of Medicine Faculty of Health Sciences University of Cape Town |
| spellingShingle | Medicine Zungu, Makhosazane Characterization of molecular and functional changes regulating hypobaric hypoxia-induced right ventricular hypertrophy |
| thesis_degree_str | Doctoral |
| title | Characterization of molecular and functional changes regulating hypobaric hypoxia-induced right ventricular hypertrophy |
| title_full | Characterization of molecular and functional changes regulating hypobaric hypoxia-induced right ventricular hypertrophy |
| title_fullStr | Characterization of molecular and functional changes regulating hypobaric hypoxia-induced right ventricular hypertrophy |
| title_full_unstemmed | Characterization of molecular and functional changes regulating hypobaric hypoxia-induced right ventricular hypertrophy |
| title_short | Characterization of molecular and functional changes regulating hypobaric hypoxia-induced right ventricular hypertrophy |
| title_sort | characterization of molecular and functional changes regulating hypobaric hypoxia induced right ventricular hypertrophy |
| topic | Medicine |
| url | http://hdl.handle.net/11427/3498 |
| work_keys_str_mv | AT zungumakhosazane characterizationofmolecularandfunctionalchangesregulatinghypobarichypoxiainducedrightventricularhypertrophy |