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The role of von Willebrand factor and its cleaving protease, ADAMTS13, in young patients with HIV-related stroke.
Includes abstract.
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
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Department of Medicine
2014
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| _version_ | 1867613330504417280 |
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| access_status_str | Open Access |
| author | Allie, Sameera |
| author2 | Combrinck, Marc |
| author_browse | Allie, Sameera Combrinck, Marc |
| author_facet | Combrinck, Marc Allie, Sameera |
| author_sort | Allie, Sameera |
| collection | Thesis |
| description | Includes abstract. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/3501 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:34:25.395Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Department of Medicine |
| publisherStr | Department of Medicine |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/3501 The role of von Willebrand factor and its cleaving protease, ADAMTS13, in young patients with HIV-related stroke. Allie, Sameera Combrinck, Marc Medicine Includes abstract. Includes bibliographical references. The Human Immunodeficiency Virus (HIV) is neuro-invasive and neurological complications of HIV infection occur frequently through a variety of possible mechanisms. Stroke in the setting of HIV is not uncommonly seen in young adults. High levels of von Willebrand factor (VWF), a protein with key roles in platelet adhesion and aggregation, and low levels of A Disintegrin and Metalloproteinase with a Thrombospondin type 1 motif, member 13 (ADAMTS13), the protease that cleaves ultra large VWF multimers into smaller less haemostatically active multimers, have been associated with an increased propensity for thrombosis. Stroke is a potential complication of the aberrant activity of these two proteins. HIV infection has also been associated with endothelial dysfunction, and VWF is a marker of the latter. The investigation of VWF and ADAMTS13 may therefore provide new insights into the pathogenesis of HIV-related stroke. 2014-07-29T09:38:54Z 2014-07-29T09:38:54Z 2013 Master Thesis Masters MSc http://hdl.handle.net/11427/3501 eng application/pdf Department of Medicine Faculty of Health Sciences University of Cape Town |
| spellingShingle | Medicine Allie, Sameera The role of von Willebrand factor and its cleaving protease, ADAMTS13, in young patients with HIV-related stroke. |
| thesis_degree_str | Master's |
| title | The role of von Willebrand factor and its cleaving protease, ADAMTS13, in young patients with HIV-related stroke. |
| title_full | The role of von Willebrand factor and its cleaving protease, ADAMTS13, in young patients with HIV-related stroke. |
| title_fullStr | The role of von Willebrand factor and its cleaving protease, ADAMTS13, in young patients with HIV-related stroke. |
| title_full_unstemmed | The role of von Willebrand factor and its cleaving protease, ADAMTS13, in young patients with HIV-related stroke. |
| title_short | The role of von Willebrand factor and its cleaving protease, ADAMTS13, in young patients with HIV-related stroke. |
| title_sort | role of von willebrand factor and its cleaving protease adamts13 in young patients with hiv related stroke |
| topic | Medicine |
| url | http://hdl.handle.net/11427/3501 |
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