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The relevance of performing 24-hour ambulatory blood pressure And pulse wave analysis in kidney transplant recipients
Hypertension guidelines recommend out of office blood pressure (BP) measurement especially 24- hour ambulatory measurement (ABPM), to diagnose and manage hypertension but this is not routinely performed in kidney transplant units. This study was to determine if 24-hour ABPM, compared with office BP...
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| Format: | Thesis |
| Language: | English |
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Department of Medicine
2022
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| _version_ | 1867613286853246976 |
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| access_status_str | Open Access |
| author | Mzingeli, Luvuyo |
| author2 | Rayner, Brian |
| author_browse | Mzingeli, Luvuyo Rayner, Brian |
| author_facet | Rayner, Brian Mzingeli, Luvuyo |
| author_sort | Mzingeli, Luvuyo |
| collection | Thesis |
| description | Hypertension guidelines recommend out of office blood pressure (BP) measurement especially 24- hour ambulatory measurement (ABPM), to diagnose and manage hypertension but this is not routinely performed in kidney transplant units. This study was to determine if 24-hour ABPM, compared with office BP in kidney transplant recipients, would be more informative regarding BP management, and if pulse wave analysis (PWA) would assist in risk stratification. This study included patients older than 18 years, with working graft kidney for >12 months, and without problems affecting BP measurement and interpretation. After performing office BP measurements, a 24-hour ABPM with additional capability of calculating pulse wave velocity (PWV),augmentation index and central BP was undertaken. Patients were assessed for controlled hypertension, uncontrolled hypertension, masked hypertension, nocturnal hypertension, white coat hypertension, and dipping BP status. Data were analysed using standard statistical tests. Of 30 patients, 15 were Black Africans and 15 were of Mixed Ancestry with a mean age of 48.9 years. Seventeen patients were males and 36.7% had controlled hypertension, 30% uncontrolled hypertension, 6.7% white coat hypertension and 33.3% masked hypertension, of whom 70% had isolated nocturnal hypertension. 70% had a non-dipping, 26.7% a reverse dipping and only 3.3% had a normal dipping BP pattern. The mean difference between brachia! systolic BP and central systolic BP was 10.4 mm Hg, whereas PWV and augmentation index were similar to healthy populations. CONCLUSION: In kidney transplant recipients, 24-hour ABPM was superior to office BP in defining hypertensive status that qualified for modification of therapy but PWA did not contribute to risk assessment. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/36031 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:33:43.673Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | Department of Medicine |
| publisherStr | Department of Medicine |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/36031 The relevance of performing 24-hour ambulatory blood pressure And pulse wave analysis in kidney transplant recipients Mzingeli, Luvuyo Rayner, Brian Hypertension kidney transplant recipients blood pressure measurement pulse wave analysis Hypertension guidelines recommend out of office blood pressure (BP) measurement especially 24- hour ambulatory measurement (ABPM), to diagnose and manage hypertension but this is not routinely performed in kidney transplant units. This study was to determine if 24-hour ABPM, compared with office BP in kidney transplant recipients, would be more informative regarding BP management, and if pulse wave analysis (PWA) would assist in risk stratification. This study included patients older than 18 years, with working graft kidney for >12 months, and without problems affecting BP measurement and interpretation. After performing office BP measurements, a 24-hour ABPM with additional capability of calculating pulse wave velocity (PWV),augmentation index and central BP was undertaken. Patients were assessed for controlled hypertension, uncontrolled hypertension, masked hypertension, nocturnal hypertension, white coat hypertension, and dipping BP status. Data were analysed using standard statistical tests. Of 30 patients, 15 were Black Africans and 15 were of Mixed Ancestry with a mean age of 48.9 years. Seventeen patients were males and 36.7% had controlled hypertension, 30% uncontrolled hypertension, 6.7% white coat hypertension and 33.3% masked hypertension, of whom 70% had isolated nocturnal hypertension. 70% had a non-dipping, 26.7% a reverse dipping and only 3.3% had a normal dipping BP pattern. The mean difference between brachia! systolic BP and central systolic BP was 10.4 mm Hg, whereas PWV and augmentation index were similar to healthy populations. CONCLUSION: In kidney transplant recipients, 24-hour ABPM was superior to office BP in defining hypertensive status that qualified for modification of therapy but PWA did not contribute to risk assessment. 2022-03-10T10:25:13Z 2022-03-10T10:25:13Z 2021 2022-03-08T09:33:36Z Master Thesis Masters MPhil http://hdl.handle.net/11427/36031 eng application/pdf Department of Medicine Faculty of Health Sciences |
| spellingShingle | Hypertension kidney transplant recipients blood pressure measurement pulse wave analysis Mzingeli, Luvuyo The relevance of performing 24-hour ambulatory blood pressure And pulse wave analysis in kidney transplant recipients |
| thesis_degree_str | Master's |
| title | The relevance of performing 24-hour ambulatory blood pressure And pulse wave analysis in kidney transplant recipients |
| title_full | The relevance of performing 24-hour ambulatory blood pressure And pulse wave analysis in kidney transplant recipients |
| title_fullStr | The relevance of performing 24-hour ambulatory blood pressure And pulse wave analysis in kidney transplant recipients |
| title_full_unstemmed | The relevance of performing 24-hour ambulatory blood pressure And pulse wave analysis in kidney transplant recipients |
| title_short | The relevance of performing 24-hour ambulatory blood pressure And pulse wave analysis in kidney transplant recipients |
| title_sort | relevance of performing 24 hour ambulatory blood pressure and pulse wave analysis in kidney transplant recipients |
| topic | Hypertension kidney transplant recipients blood pressure measurement pulse wave analysis |
| url | http://hdl.handle.net/11427/36031 |
| work_keys_str_mv | AT mzingeliluvuyo therelevanceofperforming24hourambulatorybloodpressureandpulsewaveanalysisinkidneytransplantrecipients AT mzingeliluvuyo relevanceofperforming24hourambulatorybloodpressureandpulsewaveanalysisinkidneytransplantrecipients |