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Is the Adams D-15 colour vision test a sensitive screening tool for ethambutol- and linezolid-induced optic neuropathy? A retrospective case series

Background: Ethambutol hydrochloride and linezolid are commonly used anti-tuberculous agents. Both agents can cause potentially blinding toxic optic neuropathy. Currently there is no low-cost, sensitive screening tool to detect early toxicity before permanent vision loss has occurred. Purpose: To ev...

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Main Author: Van der Merwe, Pieter Jacobus Stephanus
Other Authors: Tinley, Christopher
Format: Thesis
Language:English
Published: Division of General Surgery 2022
Subjects:
Ophthalmology
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access_status_str Open Access
author Van der Merwe, Pieter Jacobus Stephanus
author2 Tinley, Christopher
author_browse Tinley, Christopher
Van der Merwe, Pieter Jacobus Stephanus
author_facet Tinley, Christopher
Van der Merwe, Pieter Jacobus Stephanus
author_sort Van der Merwe, Pieter Jacobus Stephanus
collection Thesis
description Background: Ethambutol hydrochloride and linezolid are commonly used anti-tuberculous agents. Both agents can cause potentially blinding toxic optic neuropathy. Currently there is no low-cost, sensitive screening tool to detect early toxicity before permanent vision loss has occurred. Purpose: To evaluate the ability of the Adams D-15 colour vision test to detect early ethambutol- and linezolid-induced optic neuropathy. Methods: This was a retrospective case series of 15 patients who were screened for ethambutol- and linezolid-induced toxic optic neuropathy. At screening and follow-up visits, a detailed clinical history was taken, a standard of care examination performed and a battery of side-room investigations conducted, including: Farnsworth Munsell D15 (FM D15) and Adams D15 colour vision tests, retinal nerve fiber layer optical coherence tomography (RNFL-OCT) and a Humphrey visual field 24-2 (HVF 24-2). According to the results of these tests, the patients were classified into 3 groups: “No toxicity”, “Uncertain toxicity” or “Confirmed toxicity”. Results: Six patients were classified as “No toxicity”, 3 were “Uncertain toxicity” and 6 were classified as “Confirmed toxicity”. The Adams D15 showed a sensitivity of 100% for detecting a toxic optic neuropathy. Conclusion: The Adams D15 is a sensitive screening tool for the detection of early ethambutol- and linezolid-induced optic neuropathy.
format Thesis
id oai:open.uct.ac.za:11427/36200
institution University of Cape Town (South Africa)
language eng
last_indexed 2026-06-10T12:32:05.102Z
license_str Not specified — see source repository
provenance_str_mv Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository
publishDate 2022
publishDateRange 2022
publishDateSort 2022
publisher Division of General Surgery
publisherStr Division of General Surgery
record_format dspace
source_str UCTD — University of Cape Town Open Access Repository
spelling oai:open.uct.ac.za:11427/36200 Is the Adams D-15 colour vision test a sensitive screening tool for ethambutol- and linezolid-induced optic neuropathy? A retrospective case series Van der Merwe, Pieter Jacobus Stephanus Tinley, Christopher Ophthalmology Background: Ethambutol hydrochloride and linezolid are commonly used anti-tuberculous agents. Both agents can cause potentially blinding toxic optic neuropathy. Currently there is no low-cost, sensitive screening tool to detect early toxicity before permanent vision loss has occurred. Purpose: To evaluate the ability of the Adams D-15 colour vision test to detect early ethambutol- and linezolid-induced optic neuropathy. Methods: This was a retrospective case series of 15 patients who were screened for ethambutol- and linezolid-induced toxic optic neuropathy. At screening and follow-up visits, a detailed clinical history was taken, a standard of care examination performed and a battery of side-room investigations conducted, including: Farnsworth Munsell D15 (FM D15) and Adams D15 colour vision tests, retinal nerve fiber layer optical coherence tomography (RNFL-OCT) and a Humphrey visual field 24-2 (HVF 24-2). According to the results of these tests, the patients were classified into 3 groups: “No toxicity”, “Uncertain toxicity” or “Confirmed toxicity”. Results: Six patients were classified as “No toxicity”, 3 were “Uncertain toxicity” and 6 were classified as “Confirmed toxicity”. The Adams D15 showed a sensitivity of 100% for detecting a toxic optic neuropathy. Conclusion: The Adams D15 is a sensitive screening tool for the detection of early ethambutol- and linezolid-induced optic neuropathy. 2022-03-22T10:36:17Z 2022-03-22T10:36:17Z 2021 2022-03-22T07:08:52Z Master Thesis Masters MMed http://hdl.handle.net/11427/36200 eng application/pdf Division of General Surgery Faculty of Health Sciences
spellingShingle Ophthalmology
Van der Merwe, Pieter Jacobus Stephanus
Is the Adams D-15 colour vision test a sensitive screening tool for ethambutol- and linezolid-induced optic neuropathy? A retrospective case series
thesis_degree_str Master's
title Is the Adams D-15 colour vision test a sensitive screening tool for ethambutol- and linezolid-induced optic neuropathy? A retrospective case series
title_full Is the Adams D-15 colour vision test a sensitive screening tool for ethambutol- and linezolid-induced optic neuropathy? A retrospective case series
title_fullStr Is the Adams D-15 colour vision test a sensitive screening tool for ethambutol- and linezolid-induced optic neuropathy? A retrospective case series
title_full_unstemmed Is the Adams D-15 colour vision test a sensitive screening tool for ethambutol- and linezolid-induced optic neuropathy? A retrospective case series
title_short Is the Adams D-15 colour vision test a sensitive screening tool for ethambutol- and linezolid-induced optic neuropathy? A retrospective case series
title_sort is the adams d 15 colour vision test a sensitive screening tool for ethambutol and linezolid induced optic neuropathy a retrospective case series
topic Ophthalmology
url http://hdl.handle.net/11427/36200
work_keys_str_mv AT vandermerwepieterjacobusstephanus istheadamsd15colourvisiontestasensitivescreeningtoolforethambutolandlinezolidinducedopticneuropathyaretrospectivecaseseries

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