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Sentinel Lymph Node Biopsy in a Resource Limited Setting: A Retrospective Comparison of Sentinel Lymph Node Biopsy before and after the introduction of SentiMag at an Academic Breast Unit
Background: Sentinel lymph node biopsy (SLNB) is performed for the staging and prognostication of breast cancer in cases with a clinically and radiologically negative axilla. Using blue dye and a radioactive colloid injection is considered the gold standard for SLNB. This study aims to evaluate the...
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| Format: | Thesis |
| Language: | English |
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Division of General Surgery
2023
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| _version_ | 1867613156438704128 |
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| access_status_str | Open Access |
| author | Yousef, Mazen Mohamed S |
| author2 | Malherbe, Francois |
| author_browse | Malherbe, Francois Yousef, Mazen Mohamed S |
| author_facet | Malherbe, Francois Yousef, Mazen Mohamed S |
| author_sort | Yousef, Mazen Mohamed S |
| collection | Thesis |
| description | Background: Sentinel lymph node biopsy (SLNB) is performed for the staging and prognostication of breast cancer in cases with a clinically and radiologically negative axilla. Using blue dye and a radioactive colloid injection is considered the gold standard for SLNB. This study aims to evaluate the SLNB outcomes before and after the introduction of SentiMag at an academic breast unit Methods: A retrospective cohort study was performed comparing SLNBs done from (1 January 2017 to 31 December 2017) and (1 January 2018 to 31 December 2018). During 2017 all SLNBs were done with a nuclear medicine technique and in 2018 the Sentimag system was used. Results: There was no difference between the 2 groups comparing age, T-stage, size of tumour, grade of tumour and molecular status. The only statistically significant difference found was more higher-grade tumours in the group where a nuclear medicine technique was used (2017) p=0.04. There was no difference in the type of surgery performed comparing mastectomy and breast conserving surgery rates between the 2 groups. There was an 11% increase in the number of patients who had a SLNB done with the SentiMag technique (2018). In 2017 42% (58/139) had a SLNB and in 2018 53% (59/112) had a SLNB Conclusion: This result demonstrates the feasibility of the magnetic technique for SLNB in a resource constrained low- and middle-income country. This new method has none of the disadvantages of the standard technique and is promising as a safe and effective alternative in the absence of nuclear medicine facilities. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/36933 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:31:38.662Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | Division of General Surgery |
| publisherStr | Division of General Surgery |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/36933 Sentinel Lymph Node Biopsy in a Resource Limited Setting: A Retrospective Comparison of Sentinel Lymph Node Biopsy before and after the introduction of SentiMag at an Academic Breast Unit Yousef, Mazen Mohamed S Malherbe, Francois Surgery Background: Sentinel lymph node biopsy (SLNB) is performed for the staging and prognostication of breast cancer in cases with a clinically and radiologically negative axilla. Using blue dye and a radioactive colloid injection is considered the gold standard for SLNB. This study aims to evaluate the SLNB outcomes before and after the introduction of SentiMag at an academic breast unit Methods: A retrospective cohort study was performed comparing SLNBs done from (1 January 2017 to 31 December 2017) and (1 January 2018 to 31 December 2018). During 2017 all SLNBs were done with a nuclear medicine technique and in 2018 the Sentimag system was used. Results: There was no difference between the 2 groups comparing age, T-stage, size of tumour, grade of tumour and molecular status. The only statistically significant difference found was more higher-grade tumours in the group where a nuclear medicine technique was used (2017) p=0.04. There was no difference in the type of surgery performed comparing mastectomy and breast conserving surgery rates between the 2 groups. There was an 11% increase in the number of patients who had a SLNB done with the SentiMag technique (2018). In 2017 42% (58/139) had a SLNB and in 2018 53% (59/112) had a SLNB Conclusion: This result demonstrates the feasibility of the magnetic technique for SLNB in a resource constrained low- and middle-income country. This new method has none of the disadvantages of the standard technique and is promising as a safe and effective alternative in the absence of nuclear medicine facilities. 2023-02-21T13:15:04Z 2023-02-21T13:15:04Z 2022 2023-02-21T07:33:30Z Master Thesis Masters MMed http://hdl.handle.net/11427/36933 eng application/pdf Division of General Surgery Faculty of Health Sciences |
| spellingShingle | Surgery Yousef, Mazen Mohamed S Sentinel Lymph Node Biopsy in a Resource Limited Setting: A Retrospective Comparison of Sentinel Lymph Node Biopsy before and after the introduction of SentiMag at an Academic Breast Unit |
| thesis_degree_str | Master's |
| title | Sentinel Lymph Node Biopsy in a Resource Limited Setting: A Retrospective Comparison of Sentinel Lymph Node Biopsy before and after the introduction of SentiMag at an Academic Breast Unit |
| title_full | Sentinel Lymph Node Biopsy in a Resource Limited Setting: A Retrospective Comparison of Sentinel Lymph Node Biopsy before and after the introduction of SentiMag at an Academic Breast Unit |
| title_fullStr | Sentinel Lymph Node Biopsy in a Resource Limited Setting: A Retrospective Comparison of Sentinel Lymph Node Biopsy before and after the introduction of SentiMag at an Academic Breast Unit |
| title_full_unstemmed | Sentinel Lymph Node Biopsy in a Resource Limited Setting: A Retrospective Comparison of Sentinel Lymph Node Biopsy before and after the introduction of SentiMag at an Academic Breast Unit |
| title_short | Sentinel Lymph Node Biopsy in a Resource Limited Setting: A Retrospective Comparison of Sentinel Lymph Node Biopsy before and after the introduction of SentiMag at an Academic Breast Unit |
| title_sort | sentinel lymph node biopsy in a resource limited setting a retrospective comparison of sentinel lymph node biopsy before and after the introduction of sentimag at an academic breast unit |
| topic | Surgery |
| url | http://hdl.handle.net/11427/36933 |
| work_keys_str_mv | AT yousefmazenmohameds sentinellymphnodebiopsyinaresourcelimitedsettingaretrospectivecomparisonofsentinellymphnodebiopsybeforeandaftertheintroductionofsentimagatanacademicbreastunit |