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Assessment of the interobserver and the intra observer reproducibility for the detection of renal cortical defects in adults and children using [99mtc]Tc-MAG3
Objectives: One can assess cortical defects on the early images of [99mTc]Tc-MAG3 renography. We aim to assess interobserver and intraobserver reproducibility for detecting renal cortical defects using [ 99mTc]Tc-MAG3 for adults and children; identify causes for poor inter- and intraobserver reprodu...
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| Format: | Thesis |
| Language: | English |
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Division of Radiology
2023
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| _version_ | 1867613333449867264 |
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| access_status_str | Open Access |
| author | Hashlan, Mohammed Hussain |
| author2 | Brink, Anita |
| author_browse | Brink, Anita Hashlan, Mohammed Hussain |
| author_facet | Brink, Anita Hashlan, Mohammed Hussain |
| author_sort | Hashlan, Mohammed Hussain |
| collection | Thesis |
| description | Objectives: One can assess cortical defects on the early images of [99mTc]Tc-MAG3 renography. We aim to assess interobserver and intraobserver reproducibility for detecting renal cortical defects using [ 99mTc]Tc-MAG3 for adults and children; identify causes for poor inter- and intraobserver reproducibility and to assess the effect of the kidney to background ratio (KTBR) on reproducibility. Methods: A 100 adult and 200 paediatric renograms were included. The observers reviewed the summed 1- min posterior images for the first four minutes to detect cortical defects. Interobserver reproducibility between three observers and intra-observer reproducibility for two observers were determined. Agreement was tested using percentage agreement, Krippendorff's reliability coefficient alpha and Cohen's kappa statistic. The association between KTBR and agreement was assessed. Results: Interobserver agreement on the 1-2 minute images was 78 (95% CI: 74.8 - 82.7%) and 79.7 (95% CI: 75.9 - 83.5%) for left and right kidneys respectively. Intraobserver percentage was 89.7% (95% CI: 86.2 - 93.1%) for the senior and 80.7% (95% CI: 76.2 - 85.2%) for the junior observer. In 13.5% (27) of the adult and 4.5% (19) of the paediatric kidneys the difference in image interpretation between the observers would have had a clinical impact. If the KTBR is ≤ 2, the percentage agreement was between 61.5% and 64.8%. In cases with a KTBR > 2, the percentage agreement was between 83.6% and 87.1%. Conclusion: The percentage interobserver agreement was moderate. Disagreement between normal and abnormal cases were infrequent. The interobserver reproducibility was decreased when the KTBR was ≤ 2. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/37397 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:34:28.941Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | Division of Radiology |
| publisherStr | Division of Radiology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/37397 Assessment of the interobserver and the intra observer reproducibility for the detection of renal cortical defects in adults and children using [99mtc]Tc-MAG3 Hashlan, Mohammed Hussain Brink, Anita Nuclear Medicine Objectives: One can assess cortical defects on the early images of [99mTc]Tc-MAG3 renography. We aim to assess interobserver and intraobserver reproducibility for detecting renal cortical defects using [ 99mTc]Tc-MAG3 for adults and children; identify causes for poor inter- and intraobserver reproducibility and to assess the effect of the kidney to background ratio (KTBR) on reproducibility. Methods: A 100 adult and 200 paediatric renograms were included. The observers reviewed the summed 1- min posterior images for the first four minutes to detect cortical defects. Interobserver reproducibility between three observers and intra-observer reproducibility for two observers were determined. Agreement was tested using percentage agreement, Krippendorff's reliability coefficient alpha and Cohen's kappa statistic. The association between KTBR and agreement was assessed. Results: Interobserver agreement on the 1-2 minute images was 78 (95% CI: 74.8 - 82.7%) and 79.7 (95% CI: 75.9 - 83.5%) for left and right kidneys respectively. Intraobserver percentage was 89.7% (95% CI: 86.2 - 93.1%) for the senior and 80.7% (95% CI: 76.2 - 85.2%) for the junior observer. In 13.5% (27) of the adult and 4.5% (19) of the paediatric kidneys the difference in image interpretation between the observers would have had a clinical impact. If the KTBR is ≤ 2, the percentage agreement was between 61.5% and 64.8%. In cases with a KTBR > 2, the percentage agreement was between 83.6% and 87.1%. Conclusion: The percentage interobserver agreement was moderate. Disagreement between normal and abnormal cases were infrequent. The interobserver reproducibility was decreased when the KTBR was ≤ 2. 2023-03-13T11:54:36Z 2023-03-13T11:54:36Z 2022 2023-02-20T12:55:11Z Master Thesis Masters MMed http://hdl.handle.net/11427/37397 eng application/pdf Division of Radiology Faculty of Health Sciences |
| spellingShingle | Nuclear Medicine Hashlan, Mohammed Hussain Assessment of the interobserver and the intra observer reproducibility for the detection of renal cortical defects in adults and children using [99mtc]Tc-MAG3 |
| thesis_degree_str | Master's |
| title | Assessment of the interobserver and the intra observer reproducibility for the detection of renal cortical defects in adults and children using [99mtc]Tc-MAG3 |
| title_full | Assessment of the interobserver and the intra observer reproducibility for the detection of renal cortical defects in adults and children using [99mtc]Tc-MAG3 |
| title_fullStr | Assessment of the interobserver and the intra observer reproducibility for the detection of renal cortical defects in adults and children using [99mtc]Tc-MAG3 |
| title_full_unstemmed | Assessment of the interobserver and the intra observer reproducibility for the detection of renal cortical defects in adults and children using [99mtc]Tc-MAG3 |
| title_short | Assessment of the interobserver and the intra observer reproducibility for the detection of renal cortical defects in adults and children using [99mtc]Tc-MAG3 |
| title_sort | assessment of the interobserver and the intra observer reproducibility for the detection of renal cortical defects in adults and children using 99mtc tc mag3 |
| topic | Nuclear Medicine |
| url | http://hdl.handle.net/11427/37397 |
| work_keys_str_mv | AT hashlanmohammedhussain assessmentoftheinterobserverandtheintraobserverreproducibilityforthedetectionofrenalcorticaldefectsinadultsandchildrenusing99mtctcmag3 |