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The role of serial lactate and liver enzyme dynamics in predicting post hepatectomy liver failure
Background: Post-hepatectomy liver failure (PHLF) is an important cause of morbidity and mortality following liver resection. Current prognostic models only allow for the detection of PHLF on post-operative day 5. Earlier detection and intervention may improve outcomes. To date, no studies have eval...
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| Format: | Thesis |
| Language: | English |
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Division of General Surgery
2023
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| _version_ | 1867613490623021056 |
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| access_status_str | Open Access |
| author | Soldati, Vuyolwethu Sonwabile |
| author2 | Bernon, Marc |
| author_browse | Bernon, Marc Soldati, Vuyolwethu Sonwabile |
| author_facet | Bernon, Marc Soldati, Vuyolwethu Sonwabile |
| author_sort | Soldati, Vuyolwethu Sonwabile |
| collection | Thesis |
| description | Background: Post-hepatectomy liver failure (PHLF) is an important cause of morbidity and mortality following liver resection. Current prognostic models only allow for the detection of PHLF on post-operative day 5. Earlier detection and intervention may improve outcomes. To date, no studies have evaluated serial post-operative lactate and liver function tests (LFT) to predict PHLF. Aim: This study evaluated the prognostic utility of serial lactate concentrations and LFTs to predict PHLF following hepatectomy. Methods: All major liver resections (≥ 3 Couinaud segments) undertaken at Groote Schuur Hospital and UCT Private Academic Hospital from May 2018 to April 2021 were included. Lactate levels were measured 4-hourly for the first 24 hours post hepatectomy and daily LFTs for the first 5 days. Associations between baseline patient characteristics and lactate dynamics in PHLF as well as the predictive value of lactate, INR and bilirubin were determined. Results: Forty-seven patients, mean age 56.5 (±13.2) years, of whom 24 were males were assessed. Five (10.6%) patients had PHLF and were older (67.4 ± 12.2) and were predominantly men (80%)... |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/37799 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:36:58.981Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | Division of General Surgery |
| publisherStr | Division of General Surgery |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/37799 The role of serial lactate and liver enzyme dynamics in predicting post hepatectomy liver failure Soldati, Vuyolwethu Sonwabile Bernon, Marc Jonas, Eduard general surgery Background: Post-hepatectomy liver failure (PHLF) is an important cause of morbidity and mortality following liver resection. Current prognostic models only allow for the detection of PHLF on post-operative day 5. Earlier detection and intervention may improve outcomes. To date, no studies have evaluated serial post-operative lactate and liver function tests (LFT) to predict PHLF. Aim: This study evaluated the prognostic utility of serial lactate concentrations and LFTs to predict PHLF following hepatectomy. Methods: All major liver resections (≥ 3 Couinaud segments) undertaken at Groote Schuur Hospital and UCT Private Academic Hospital from May 2018 to April 2021 were included. Lactate levels were measured 4-hourly for the first 24 hours post hepatectomy and daily LFTs for the first 5 days. Associations between baseline patient characteristics and lactate dynamics in PHLF as well as the predictive value of lactate, INR and bilirubin were determined. Results: Forty-seven patients, mean age 56.5 (±13.2) years, of whom 24 were males were assessed. Five (10.6%) patients had PHLF and were older (67.4 ± 12.2) and were predominantly men (80%)... 2023-04-20T13:26:07Z 2023-04-20T13:26:07Z 2022 2023-04-20T13:25:47Z Master Thesis Masters MMed http://hdl.handle.net/11427/37799 eng application/pdf Division of General Surgery Faculty of Health Sciences |
| spellingShingle | general surgery Soldati, Vuyolwethu Sonwabile The role of serial lactate and liver enzyme dynamics in predicting post hepatectomy liver failure |
| thesis_degree_str | Master's |
| title | The role of serial lactate and liver enzyme dynamics in predicting post hepatectomy liver failure |
| title_full | The role of serial lactate and liver enzyme dynamics in predicting post hepatectomy liver failure |
| title_fullStr | The role of serial lactate and liver enzyme dynamics in predicting post hepatectomy liver failure |
| title_full_unstemmed | The role of serial lactate and liver enzyme dynamics in predicting post hepatectomy liver failure |
| title_short | The role of serial lactate and liver enzyme dynamics in predicting post hepatectomy liver failure |
| title_sort | role of serial lactate and liver enzyme dynamics in predicting post hepatectomy liver failure |
| topic | general surgery |
| url | http://hdl.handle.net/11427/37799 |
| work_keys_str_mv | AT soldativuyolwethusonwabile theroleofseriallactateandliverenzymedynamicsinpredictingposthepatectomyliverfailure AT soldativuyolwethusonwabile roleofseriallactateandliverenzymedynamicsinpredictingposthepatectomyliverfailure |