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Isoniazid preventative therapy penetrance at a community health centre in South Africa: a cross sectional study
Background: Tuberculosis (TB) remains a major contributor to morbidity and mortality in people living with HIV (PLHIV). The use of Isoniazid preventative therapy (IPT) has been proven to be effective and safe to reduce this burden. Despite overwhelming evidence, uptake op IPT is poor. This study eva...
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| Format: | Thesis |
| Language: | English |
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Department of Public Health and Family Medicine
2023
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| _version_ | 1867613217834926080 |
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| access_status_str | Open Access |
| author | Steyn, Johannes |
| author2 | De Vries, Elsje Maria |
| author_browse | De Vries, Elsje Maria Steyn, Johannes |
| author_facet | De Vries, Elsje Maria Steyn, Johannes |
| author_sort | Steyn, Johannes |
| collection | Thesis |
| description | Background: Tuberculosis (TB) remains a major contributor to morbidity and mortality in people living with HIV (PLHIV). The use of Isoniazid preventative therapy (IPT) has been proven to be effective and safe to reduce this burden. Despite overwhelming evidence, uptake op IPT is poor. This study evaluated an urban population of PLHIV and described associations with the delivery of IPT. Methods: A retrospective folder review. Results: A total of 198 folders were reviewed of which 31 had been/currently were on IPT. In the no-IPT group the fast majority, 86%, of the patients were eligible (according to current national HIV guidelines) for IPT. Only 4% had true contraindications. Factors favouring the delivery of IPT was the duration on ART (p=0.0038) and being part of the ART adherence club(AC) system (<0.0001). Conclusion: The vast majority of patients are screened but do not receive TPT. The duration of ART increased the likelihood of a patient to receive IPT. However, patients recently started on ART are at higher risk of TB disease and will benefit greatly from IPT. Patients who were enrolled in the AC system had a higher IPT penetrance. Quality improvement cycles should be implemented to address the situation. Increasing the role that adherence clubs play may be an option for future interventions. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/37804 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:32:38.580Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | Department of Public Health and Family Medicine |
| publisherStr | Department of Public Health and Family Medicine |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/37804 Isoniazid preventative therapy penetrance at a community health centre in South Africa: a cross sectional study Steyn, Johannes De Vries, Elsje Maria family medicine Background: Tuberculosis (TB) remains a major contributor to morbidity and mortality in people living with HIV (PLHIV). The use of Isoniazid preventative therapy (IPT) has been proven to be effective and safe to reduce this burden. Despite overwhelming evidence, uptake op IPT is poor. This study evaluated an urban population of PLHIV and described associations with the delivery of IPT. Methods: A retrospective folder review. Results: A total of 198 folders were reviewed of which 31 had been/currently were on IPT. In the no-IPT group the fast majority, 86%, of the patients were eligible (according to current national HIV guidelines) for IPT. Only 4% had true contraindications. Factors favouring the delivery of IPT was the duration on ART (p=0.0038) and being part of the ART adherence club(AC) system (<0.0001). Conclusion: The vast majority of patients are screened but do not receive TPT. The duration of ART increased the likelihood of a patient to receive IPT. However, patients recently started on ART are at higher risk of TB disease and will benefit greatly from IPT. Patients who were enrolled in the AC system had a higher IPT penetrance. Quality improvement cycles should be implemented to address the situation. Increasing the role that adherence clubs play may be an option for future interventions. 2023-04-20T14:03:59Z 2023-04-20T14:03:59Z 2022 2023-04-20T14:01:29Z Master Thesis Masters MMed http://hdl.handle.net/11427/37804 eng application/pdf Department of Public Health and Family Medicine Faculty of Health Sciences |
| spellingShingle | family medicine Steyn, Johannes Isoniazid preventative therapy penetrance at a community health centre in South Africa: a cross sectional study |
| thesis_degree_str | Master's |
| title | Isoniazid preventative therapy penetrance at a community health centre in South Africa: a cross sectional study |
| title_full | Isoniazid preventative therapy penetrance at a community health centre in South Africa: a cross sectional study |
| title_fullStr | Isoniazid preventative therapy penetrance at a community health centre in South Africa: a cross sectional study |
| title_full_unstemmed | Isoniazid preventative therapy penetrance at a community health centre in South Africa: a cross sectional study |
| title_short | Isoniazid preventative therapy penetrance at a community health centre in South Africa: a cross sectional study |
| title_sort | isoniazid preventative therapy penetrance at a community health centre in south africa a cross sectional study |
| topic | family medicine |
| url | http://hdl.handle.net/11427/37804 |
| work_keys_str_mv | AT steynjohannes isoniazidpreventativetherapypenetranceatacommunityhealthcentreinsouthafricaacrosssectionalstudy |