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Treatment outcomes of young patients with invasive breast cancer treated radically at Groote Schuur Hospital from 2013-2017: A single centre study
Treatment outcomes of young patients with invasive breast cancer treated radically at Groote Schuur Hospital from 2013 to 2017: A single centre study Background: Breast cancer is the leading cause of cancer- related deaths globally, and the commonest cancer in women under 40 years. There is currentl...
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| Format: | Thesis |
| Language: | English |
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Division of Radiology
2023
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| _version_ | 1867613225139306496 |
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| access_status_str | Open Access |
| author | Tangane, Gomolemo |
| author2 | Tselane, Thebe |
| author_browse | Tangane, Gomolemo Tselane, Thebe |
| author_facet | Tselane, Thebe Tangane, Gomolemo |
| author_sort | Tangane, Gomolemo |
| collection | Thesis |
| description | Treatment outcomes of young patients with invasive breast cancer treated radically at Groote Schuur Hospital from 2013 to 2017: A single centre study Background: Breast cancer is the leading cause of cancer- related deaths globally, and the commonest cancer in women under 40 years. There is currently a lack of data relating to treatment outcomes of young women with breast cancer particularly in low-and middle-income countries. Aim: This study aims to evaluate the treatment outcomes of young patients (under 40 years) treated radically for invasive breast cancer in a low-and middle-income setting. Settings: Groote Schuur Hospital, Cape Town, South Africa Methods: A retrospective review of 101 women under 40 years, with invasive breast cancer treated radically, between 2013 and 2017 was conducted. Patient characteristics, tumour characteristics, disease stage, treatment, and follow-up were recorded. Primary objectives included evaluating overall and disease free survival, and analysing recurrence patterns and clinicopathological features. Results: The five-year overall and disease free survival for the entire cohort was 77% and 51%, respectively. Five-year overall survival by molecular subtype showed that Luminal A had the best survival, while triple negative breast cancer had the worst overall survival. Conclusion: Young women with breast cancer have poor survival outcomes despite early presentation. There is limited data regarding breast cancer treatment outcomes in patients under forty years. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/37808 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:32:45.765Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | Division of Radiology |
| publisherStr | Division of Radiology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/37808 Treatment outcomes of young patients with invasive breast cancer treated radically at Groote Schuur Hospital from 2013-2017: A single centre study Tangane, Gomolemo Tselane, Thebe Hunter, Alistair breast cancer young women breast cancer Africa breast cancer South Africa breast cancer survival breast cancer under 40 years breast cancer treatment outcomes low and middle-income countries Treatment outcomes of young patients with invasive breast cancer treated radically at Groote Schuur Hospital from 2013 to 2017: A single centre study Background: Breast cancer is the leading cause of cancer- related deaths globally, and the commonest cancer in women under 40 years. There is currently a lack of data relating to treatment outcomes of young women with breast cancer particularly in low-and middle-income countries. Aim: This study aims to evaluate the treatment outcomes of young patients (under 40 years) treated radically for invasive breast cancer in a low-and middle-income setting. Settings: Groote Schuur Hospital, Cape Town, South Africa Methods: A retrospective review of 101 women under 40 years, with invasive breast cancer treated radically, between 2013 and 2017 was conducted. Patient characteristics, tumour characteristics, disease stage, treatment, and follow-up were recorded. Primary objectives included evaluating overall and disease free survival, and analysing recurrence patterns and clinicopathological features. Results: The five-year overall and disease free survival for the entire cohort was 77% and 51%, respectively. Five-year overall survival by molecular subtype showed that Luminal A had the best survival, while triple negative breast cancer had the worst overall survival. Conclusion: Young women with breast cancer have poor survival outcomes despite early presentation. There is limited data regarding breast cancer treatment outcomes in patients under forty years. 2023-04-20T17:13:47Z 2023-04-20T17:13:47Z 2022 2023-04-20T17:13:20Z Master Thesis Masters MMed http://hdl.handle.net/11427/37808 eng application/pdf Division of Radiology Faculty of Health Sciences |
| spellingShingle | breast cancer young women breast cancer Africa breast cancer South Africa breast cancer survival breast cancer under 40 years breast cancer treatment outcomes low and middle-income countries Tangane, Gomolemo Treatment outcomes of young patients with invasive breast cancer treated radically at Groote Schuur Hospital from 2013-2017: A single centre study |
| thesis_degree_str | Master's |
| title | Treatment outcomes of young patients with invasive breast cancer treated radically at Groote Schuur Hospital from 2013-2017: A single centre study |
| title_full | Treatment outcomes of young patients with invasive breast cancer treated radically at Groote Schuur Hospital from 2013-2017: A single centre study |
| title_fullStr | Treatment outcomes of young patients with invasive breast cancer treated radically at Groote Schuur Hospital from 2013-2017: A single centre study |
| title_full_unstemmed | Treatment outcomes of young patients with invasive breast cancer treated radically at Groote Schuur Hospital from 2013-2017: A single centre study |
| title_short | Treatment outcomes of young patients with invasive breast cancer treated radically at Groote Schuur Hospital from 2013-2017: A single centre study |
| title_sort | treatment outcomes of young patients with invasive breast cancer treated radically at groote schuur hospital from 2013 2017 a single centre study |
| topic | breast cancer young women breast cancer Africa breast cancer South Africa breast cancer survival breast cancer under 40 years breast cancer treatment outcomes low and middle-income countries |
| url | http://hdl.handle.net/11427/37808 |
| work_keys_str_mv | AT tanganegomolemo treatmentoutcomesofyoungpatientswithinvasivebreastcancertreatedradicallyatgrooteschuurhospitalfrom20132017asinglecentrestudy |