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Investigating the effects of impermeant anions on the electrical and computational properties on neurons
Impermeant anions (proteins, amino acids, etc.) are negatively charged ions that are unable to traverse the cell membrane. Impermeant anion quantities and their average charge vary with metabolism as well as protein and nucleic acid synthesis/turnover.The effect of spatiotemporal changes to impermea...
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| Format: | Thesis |
| Language: | English |
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Department of Human Biology
2023
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| _version_ | 1867613159518371840 |
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| access_status_str | Open Access |
| author | Shorer, Eran |
| author2 | Raimondo, Joseph |
| author_browse | Raimondo, Joseph Shorer, Eran |
| author_facet | Raimondo, Joseph Shorer, Eran |
| author_sort | Shorer, Eran |
| collection | Thesis |
| description | Impermeant anions (proteins, amino acids, etc.) are negatively charged ions that are unable to traverse the cell membrane. Impermeant anion quantities and their average charge vary with metabolism as well as protein and nucleic acid synthesis/turnover.The effect of spatiotemporal changes to impermeant anions on neurons is poorly understood. Using a multicompartment electrodiffusion-based computational model I investigated the influence of impermeant anions on neuronal cellular physiology, passive cable properties, and synaptic integration. Spatial differences in the average charge of impermeant anions result in a nonisopotential dendrite with ionic microdomains. At steady state local discrepancies in membrane potentials and ion concentrations do not impact the passive or active electrical properties of neurons as ionic driving forces are unchanged, irrespective of impermeant anion mean charge. These findings explain how electrical signalling remains consistent in the face of an ever-changing impermeant anion milieu with implications related to our understanding of both normal and pathological neuronal physiology. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/38163 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:31:43.046Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | Department of Human Biology |
| publisherStr | Department of Human Biology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/38163 Investigating the effects of impermeant anions on the electrical and computational properties on neurons Shorer, Eran Raimondo, Joseph Medicine Impermeant anions (proteins, amino acids, etc.) are negatively charged ions that are unable to traverse the cell membrane. Impermeant anion quantities and their average charge vary with metabolism as well as protein and nucleic acid synthesis/turnover.The effect of spatiotemporal changes to impermeant anions on neurons is poorly understood. Using a multicompartment electrodiffusion-based computational model I investigated the influence of impermeant anions on neuronal cellular physiology, passive cable properties, and synaptic integration. Spatial differences in the average charge of impermeant anions result in a nonisopotential dendrite with ionic microdomains. At steady state local discrepancies in membrane potentials and ion concentrations do not impact the passive or active electrical properties of neurons as ionic driving forces are unchanged, irrespective of impermeant anion mean charge. These findings explain how electrical signalling remains consistent in the face of an ever-changing impermeant anion milieu with implications related to our understanding of both normal and pathological neuronal physiology. 2023-07-28T06:59:52Z 2023-07-28T06:59:52Z 2023 2023-07-28T06:59:20Z Master Thesis Masters MSc http://hdl.handle.net/11427/38163 eng application/pdf Department of Human Biology Faculty of Health Sciences |
| spellingShingle | Medicine Shorer, Eran Investigating the effects of impermeant anions on the electrical and computational properties on neurons |
| thesis_degree_str | Master's |
| title | Investigating the effects of impermeant anions on the electrical and computational properties on neurons |
| title_full | Investigating the effects of impermeant anions on the electrical and computational properties on neurons |
| title_fullStr | Investigating the effects of impermeant anions on the electrical and computational properties on neurons |
| title_full_unstemmed | Investigating the effects of impermeant anions on the electrical and computational properties on neurons |
| title_short | Investigating the effects of impermeant anions on the electrical and computational properties on neurons |
| title_sort | investigating the effects of impermeant anions on the electrical and computational properties on neurons |
| topic | Medicine |
| url | http://hdl.handle.net/11427/38163 |
| work_keys_str_mv | AT shorereran investigatingtheeffectsofimpermeantanionsontheelectricalandcomputationalpropertiesonneurons |