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Characterisation of phenotypes of inflammation, fibrosis and remodeling in chronic rheumatic heart disease using multiparametric cardiovascular magnetic resonance and autophagy markers

Background: Rheumatic heart disease (RHD), concomitant to valvular damage, heart failure, arrhythmias and pulmonary hypertension is the major source of cardiovascular morbidity and mortality in the young, predominantly in low- and middle-income countries (LMICs). We investigated the association of v...

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Main Author: Aremu, Olukayode Olasunkanmi
Other Authors: Ntusi, Ntobeko
Format: Thesis
Language:English
Published: Department of Medicine 2023
Subjects:
cardiovascular magnetic resonance
autophagy
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access_status_str Open Access
author Aremu, Olukayode Olasunkanmi
author2 Ntusi, Ntobeko
author_browse Aremu, Olukayode Olasunkanmi
Ntusi, Ntobeko
author_facet Ntusi, Ntobeko
Aremu, Olukayode Olasunkanmi
author_sort Aremu, Olukayode Olasunkanmi
collection Thesis
description Background: Rheumatic heart disease (RHD), concomitant to valvular damage, heart failure, arrhythmias and pulmonary hypertension is the major source of cardiovascular morbidity and mortality in the young, predominantly in low- and middle-income countries (LMICs). We investigated the association of valve lesions in RHD with cardiovascular magnetic resonance (CMR) tissue characteristics and autophagy markers, in this study. Methods: Forty-seven (47) patients (42 ± 12.8 years), with advanced RHD, awaiting valve replacement, confirmed on echocardiography, and matched with 30 healthy controls (39 ± 12.1 years), were scanned using a 3T Siemens Magnetom Skyra. CMR parameters were derived from the following acquisitions: cine imaging of the short and long axes, T1 mapping (MOLLI, 5(3)3, estimation of ECV and late gadolinium enhancement (LGE) imaging. For the cellular study, we analysed the immunoexpression of Beclin, LC3, p62, BAX, Bcl-2 and caspase-3 in patients confirmed with RHD and valvular heart disease
format Thesis
id oai:open.uct.ac.za:11427/38460
institution University of Cape Town (South Africa)
language eng
last_indexed 2026-06-10T12:33:51.607Z
license_str Not specified — see source repository
provenance_str_mv Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository
publishDate 2023
publishDateRange 2023
publishDateSort 2023
publisher Department of Medicine
publisherStr Department of Medicine
record_format dspace
source_str UCTD — University of Cape Town Open Access Repository
spelling oai:open.uct.ac.za:11427/38460 Characterisation of phenotypes of inflammation, fibrosis and remodeling in chronic rheumatic heart disease using multiparametric cardiovascular magnetic resonance and autophagy markers Aremu, Olukayode Olasunkanmi Ntusi, Ntobeko Skatulla, Sebastian cardiovascular magnetic resonance autophagy Background: Rheumatic heart disease (RHD), concomitant to valvular damage, heart failure, arrhythmias and pulmonary hypertension is the major source of cardiovascular morbidity and mortality in the young, predominantly in low- and middle-income countries (LMICs). We investigated the association of valve lesions in RHD with cardiovascular magnetic resonance (CMR) tissue characteristics and autophagy markers, in this study. Methods: Forty-seven (47) patients (42 ± 12.8 years), with advanced RHD, awaiting valve replacement, confirmed on echocardiography, and matched with 30 healthy controls (39 ± 12.1 years), were scanned using a 3T Siemens Magnetom Skyra. CMR parameters were derived from the following acquisitions: cine imaging of the short and long axes, T1 mapping (MOLLI, 5(3)3, estimation of ECV and late gadolinium enhancement (LGE) imaging. For the cellular study, we analysed the immunoexpression of Beclin, LC3, p62, BAX, Bcl-2 and caspase-3 in patients confirmed with RHD and valvular heart disease 2023-09-08T10:31:11Z 2023-09-08T10:31:11Z 2023 2023-09-08T10:11:50Z Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/38460 eng application/pdf Department of Medicine Faculty of Health Sciences
spellingShingle cardiovascular magnetic resonance
autophagy
Aremu, Olukayode Olasunkanmi
Characterisation of phenotypes of inflammation, fibrosis and remodeling in chronic rheumatic heart disease using multiparametric cardiovascular magnetic resonance and autophagy markers
thesis_degree_str Doctoral
title Characterisation of phenotypes of inflammation, fibrosis and remodeling in chronic rheumatic heart disease using multiparametric cardiovascular magnetic resonance and autophagy markers
title_full Characterisation of phenotypes of inflammation, fibrosis and remodeling in chronic rheumatic heart disease using multiparametric cardiovascular magnetic resonance and autophagy markers
title_fullStr Characterisation of phenotypes of inflammation, fibrosis and remodeling in chronic rheumatic heart disease using multiparametric cardiovascular magnetic resonance and autophagy markers
title_full_unstemmed Characterisation of phenotypes of inflammation, fibrosis and remodeling in chronic rheumatic heart disease using multiparametric cardiovascular magnetic resonance and autophagy markers
title_short Characterisation of phenotypes of inflammation, fibrosis and remodeling in chronic rheumatic heart disease using multiparametric cardiovascular magnetic resonance and autophagy markers
title_sort characterisation of phenotypes of inflammation fibrosis and remodeling in chronic rheumatic heart disease using multiparametric cardiovascular magnetic resonance and autophagy markers
topic cardiovascular magnetic resonance
autophagy
url http://hdl.handle.net/11427/38460
work_keys_str_mv AT aremuolukayodeolasunkanmi characterisationofphenotypesofinflammationfibrosisandremodelinginchronicrheumaticheartdiseaseusingmultiparametriccardiovascularmagneticresonanceandautophagymarkers

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