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An exploration of the molecular mechanisms underlying the effects of hyperglycaemia on the autorrhythmicity of cardiac-like stem cells
Introduction Diabetes mellitus with uncontrolled hyperglycaemia is a major risk factor for heart rhythm disturbances. Hyperglycaemia during pregnancy is particularly concerning, as offspring of poorly controlled diabetic mothers are at an increased risk of developing life-long serious cardiovascular...
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| Format: | Thesis |
| Language: | English |
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Department of Human Biology
2024
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| _version_ | 1867613314692939776 |
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| access_status_str | Open Access |
| author | Menzele, Amanda |
| author2 | Gwanyanya, Asfree |
| author_browse | Gwanyanya, Asfree Menzele, Amanda |
| author_facet | Gwanyanya, Asfree Menzele, Amanda |
| author_sort | Menzele, Amanda |
| collection | Thesis |
| description | Introduction Diabetes mellitus with uncontrolled hyperglycaemia is a major risk factor for heart rhythm disturbances. Hyperglycaemia during pregnancy is particularly concerning, as offspring of poorly controlled diabetic mothers are at an increased risk of developing life-long serious cardiovascular complications. Although structural abnormalities such as congenital heart defects and hypertrophic cardiomyopathy are by far the most common sequelae in these infants, it is becoming increasingly apparent that a vulnerability towards malignant dysrhythmias is far more prevalent than generally reported in the literature. Unfortunately, the mechanistic link between hyperglycaemia and impaired foetal cardiac electrophysiology is poorly understood. Using a cardiac developmental cellular model, this study aimed to explore the effects of hyperglycaemia on the autorrhythmicity of mouse embryonic stem cell (mESC)-derived cardiac-like cells. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/39671 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:34:10.861Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2024 |
| publishDateRange | 2024 |
| publishDateSort | 2024 |
| publisher | Department of Human Biology |
| publisherStr | Department of Human Biology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/39671 An exploration of the molecular mechanisms underlying the effects of hyperglycaemia on the autorrhythmicity of cardiac-like stem cells Menzele, Amanda Gwanyanya, Asfree Medicine Introduction Diabetes mellitus with uncontrolled hyperglycaemia is a major risk factor for heart rhythm disturbances. Hyperglycaemia during pregnancy is particularly concerning, as offspring of poorly controlled diabetic mothers are at an increased risk of developing life-long serious cardiovascular complications. Although structural abnormalities such as congenital heart defects and hypertrophic cardiomyopathy are by far the most common sequelae in these infants, it is becoming increasingly apparent that a vulnerability towards malignant dysrhythmias is far more prevalent than generally reported in the literature. Unfortunately, the mechanistic link between hyperglycaemia and impaired foetal cardiac electrophysiology is poorly understood. Using a cardiac developmental cellular model, this study aimed to explore the effects of hyperglycaemia on the autorrhythmicity of mouse embryonic stem cell (mESC)-derived cardiac-like cells. 2024-05-21T13:02:54Z 2024-05-21T13:02:54Z 2023 2024-05-21T12:19:56Z Thesis / Dissertation Masters MSc http://hdl.handle.net/11427/39671 eng application/pdf Department of Human Biology Faculty of Health Sciences |
| spellingShingle | Medicine Menzele, Amanda An exploration of the molecular mechanisms underlying the effects of hyperglycaemia on the autorrhythmicity of cardiac-like stem cells |
| thesis_degree_str | Master's |
| title | An exploration of the molecular mechanisms underlying the effects of hyperglycaemia on the autorrhythmicity of cardiac-like stem cells |
| title_full | An exploration of the molecular mechanisms underlying the effects of hyperglycaemia on the autorrhythmicity of cardiac-like stem cells |
| title_fullStr | An exploration of the molecular mechanisms underlying the effects of hyperglycaemia on the autorrhythmicity of cardiac-like stem cells |
| title_full_unstemmed | An exploration of the molecular mechanisms underlying the effects of hyperglycaemia on the autorrhythmicity of cardiac-like stem cells |
| title_short | An exploration of the molecular mechanisms underlying the effects of hyperglycaemia on the autorrhythmicity of cardiac-like stem cells |
| title_sort | exploration of the molecular mechanisms underlying the effects of hyperglycaemia on the autorrhythmicity of cardiac like stem cells |
| topic | Medicine |
| url | http://hdl.handle.net/11427/39671 |
| work_keys_str_mv | AT menzeleamanda anexplorationofthemolecularmechanismsunderlyingtheeffectsofhyperglycaemiaontheautorrhythmicityofcardiaclikestemcells AT menzeleamanda explorationofthemolecularmechanismsunderlyingtheeffectsofhyperglycaemiaontheautorrhythmicityofcardiaclikestemcells |