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RSV infection in children hospitalised with severe lower respiratory tract infection at the Red Cross War Memorial Children's Hospital (2012-2013)

Objectives: Low- and middle-income countries carry the largest burden of Respiratory syncytial virus (RSV) disease, with most deaths occurring in these settings. This study aimed to investigate the burden of RSV disease in South African children hospitalised with lower respiratory tract infectio...

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Main Author: Morgan, Nicole
Other Authors: Muloiwa, Rudzani
Format: Thesis
Language:English
Published: Department of Paediatrics and Child Health 2024
Subjects:
Paediatrics
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access_status_str Open Access
author Morgan, Nicole
author2 Muloiwa, Rudzani
author_browse Morgan, Nicole
Muloiwa, Rudzani
author_facet Muloiwa, Rudzani
Morgan, Nicole
author_sort Morgan, Nicole
collection Thesis
description Objectives: Low- and middle-income countries carry the largest burden of Respiratory syncytial virus (RSV) disease, with most deaths occurring in these settings. This study aimed to investigate the burden of RSV disease in South African children hospitalised with lower respiratory tract infection (LRTI), with specific reference to incidence, risk factors, and co26 infections. Results: RSV was detected in 142 (30.9%; 95%CI 26.7-35.3) of the included 460 study children with LRTI. The median age of RSV-positive children was 4.6 (IQR 2.4-9.7) months compared to RSV-negative children of 10.5 (IQR 4.4-21.3) months, P = <0.001. Most cases occurred in autumn and winter with 126 (89%) cases over this period. IS demonstrated greater sensitivity for RSV diagnosis with 135 cases (95.1%) detected on IS and 57 cases (40.1%) identified on NP; P<0.001. The median length of hospital stay was 3.3 (SD 4.2) days in the RSV positive group and 2.7 (SD 3.3) days in the RSV negative group; P<0.001. The number of detected viral pathogens was a median of 1 (IQR 0-2) in RSV positive children (when RSV was excluded from the count) compared to 2 (IQR 2-3) in RSV negative children; P<0.001. The presence of RSV was independently associated with a reduction in the frequency of most viruses tested for on PCR. Conclusions: RSV is common in children hospitalised with LRTI and mainly affects younger children. There is an urgent need to find an effective vaccine to prevent RSV pneumonia in children worldwide, especially in LMICs that carry the greatest burden of disease.
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institution University of Cape Town (South Africa)
language eng
last_indexed 2026-06-10T12:32:50.328Z
license_str Not specified — see source repository
provenance_str_mv Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository
publishDate 2024
publishDateRange 2024
publishDateSort 2024
publisher Department of Paediatrics and Child Health
publisherStr Department of Paediatrics and Child Health
record_format dspace
source_str UCTD — University of Cape Town Open Access Repository
spelling oai:open.uct.ac.za:11427/39707 RSV infection in children hospitalised with severe lower respiratory tract infection at the Red Cross War Memorial Children's Hospital (2012-2013) Morgan, Nicole Muloiwa, Rudzani Ascott Heloise Paediatrics Objectives: Low- and middle-income countries carry the largest burden of Respiratory syncytial virus (RSV) disease, with most deaths occurring in these settings. This study aimed to investigate the burden of RSV disease in South African children hospitalised with lower respiratory tract infection (LRTI), with specific reference to incidence, risk factors, and co26 infections. Results: RSV was detected in 142 (30.9%; 95%CI 26.7-35.3) of the included 460 study children with LRTI. The median age of RSV-positive children was 4.6 (IQR 2.4-9.7) months compared to RSV-negative children of 10.5 (IQR 4.4-21.3) months, P = <0.001. Most cases occurred in autumn and winter with 126 (89%) cases over this period. IS demonstrated greater sensitivity for RSV diagnosis with 135 cases (95.1%) detected on IS and 57 cases (40.1%) identified on NP; P<0.001. The median length of hospital stay was 3.3 (SD 4.2) days in the RSV positive group and 2.7 (SD 3.3) days in the RSV negative group; P<0.001. The number of detected viral pathogens was a median of 1 (IQR 0-2) in RSV positive children (when RSV was excluded from the count) compared to 2 (IQR 2-3) in RSV negative children; P<0.001. The presence of RSV was independently associated with a reduction in the frequency of most viruses tested for on PCR. Conclusions: RSV is common in children hospitalised with LRTI and mainly affects younger children. There is an urgent need to find an effective vaccine to prevent RSV pneumonia in children worldwide, especially in LMICs that carry the greatest burden of disease. 2024-05-27T08:42:32Z 2024-05-27T08:42:32Z 2023 2024-05-22T08:21:37Z Thesis / Dissertation Masters MMed http://hdl.handle.net/11427/39707 eng application/pdf Department of Paediatrics and Child Health Faculty of Health Sciences
spellingShingle Paediatrics
Morgan, Nicole
RSV infection in children hospitalised with severe lower respiratory tract infection at the Red Cross War Memorial Children's Hospital (2012-2013)
thesis_degree_str Master's
title RSV infection in children hospitalised with severe lower respiratory tract infection at the Red Cross War Memorial Children's Hospital (2012-2013)
title_full RSV infection in children hospitalised with severe lower respiratory tract infection at the Red Cross War Memorial Children's Hospital (2012-2013)
title_fullStr RSV infection in children hospitalised with severe lower respiratory tract infection at the Red Cross War Memorial Children's Hospital (2012-2013)
title_full_unstemmed RSV infection in children hospitalised with severe lower respiratory tract infection at the Red Cross War Memorial Children's Hospital (2012-2013)
title_short RSV infection in children hospitalised with severe lower respiratory tract infection at the Red Cross War Memorial Children's Hospital (2012-2013)
title_sort rsv infection in children hospitalised with severe lower respiratory tract infection at the red cross war memorial children s hospital 2012 2013
topic Paediatrics
url http://hdl.handle.net/11427/39707
work_keys_str_mv AT morgannicole rsvinfectioninchildrenhospitalisedwithseverelowerrespiratorytractinfectionattheredcrosswarmemorialchildrenshospital20122013

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