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Outcomes of penetrating keratoplasty at a tertiary institution in South Africa.
Aims: To determine corneal graft survival rates and visual outcomes of penetrating keratoplasty (PKP) in a South African setting. Methods: A retrospective review of 99 penetrating keratoplasties performed at Groote Schuur Hospital, South Africa over a 3-year period between February 2016 and February...
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| Format: | Thesis |
| Language: | English |
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Division of General Surgery
2024
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| _version_ | 1867613224502820864 |
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| access_status_str | Open Access |
| author | Theron, Yolande |
| author2 | du Toit, Nagib |
| author_browse | Theron, Yolande du Toit, Nagib |
| author_facet | du Toit, Nagib Theron, Yolande |
| author_sort | Theron, Yolande |
| collection | Thesis |
| description | Aims: To determine corneal graft survival rates and visual outcomes of penetrating keratoplasty (PKP) in a South African setting. Methods: A retrospective review of 99 penetrating keratoplasties performed at Groote Schuur Hospital, South Africa over a 3-year period between February 2016 and February 2019. Results: The mean age of study participants was 38 years (14-85). The study included 60% females and 40% males. The main indications for surgery were keratoconus (58%), corneal scar (21%), regrafts (8%), pseudophakic bullous keratopathy (6%), corneal dystrophies (3%) and pellucid marginal degeneration (1%). The overall graft survival at 1-year follow up was 86%. A higher 1-year graft survival rate of 94% was seen in patients with keratoconus. The total number of patients diagnosed with graft failure at 1 year was 13.The Kaplan-Meier survival analysis was used to assess time to graft failure. The estimate was 11.7 months (mean time to graft failure) with a 95% CI confidence interval from 11.4 to 12 months. In our study, best corrected Snellen acuity in the category of 6/6-6/18 was found in 59.2% of patients 1-one year post-operatively, compared with 1% of patients in the same BCVA group pre-operatively. Patients with a BCVA equal to 3/60 or less reduced from 56% preoperatively to 20% postoperatively at 1 one year. Conclusion: Penetrating Keratoplasty is an effective long term treatment option to restore visual acuity in certain corneal disorders in a middle to low-income country. Our results demonstrated a comparable 1-year graft survival rate to high-income countries. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/39884 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:32:44.899Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2024 |
| publishDateRange | 2024 |
| publishDateSort | 2024 |
| publisher | Division of General Surgery |
| publisherStr | Division of General Surgery |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/39884 Outcomes of penetrating keratoplasty at a tertiary institution in South Africa. Theron, Yolande du Toit, Nagib General Surgery Aims: To determine corneal graft survival rates and visual outcomes of penetrating keratoplasty (PKP) in a South African setting. Methods: A retrospective review of 99 penetrating keratoplasties performed at Groote Schuur Hospital, South Africa over a 3-year period between February 2016 and February 2019. Results: The mean age of study participants was 38 years (14-85). The study included 60% females and 40% males. The main indications for surgery were keratoconus (58%), corneal scar (21%), regrafts (8%), pseudophakic bullous keratopathy (6%), corneal dystrophies (3%) and pellucid marginal degeneration (1%). The overall graft survival at 1-year follow up was 86%. A higher 1-year graft survival rate of 94% was seen in patients with keratoconus. The total number of patients diagnosed with graft failure at 1 year was 13.The Kaplan-Meier survival analysis was used to assess time to graft failure. The estimate was 11.7 months (mean time to graft failure) with a 95% CI confidence interval from 11.4 to 12 months. In our study, best corrected Snellen acuity in the category of 6/6-6/18 was found in 59.2% of patients 1-one year post-operatively, compared with 1% of patients in the same BCVA group pre-operatively. Patients with a BCVA equal to 3/60 or less reduced from 56% preoperatively to 20% postoperatively at 1 one year. Conclusion: Penetrating Keratoplasty is an effective long term treatment option to restore visual acuity in certain corneal disorders in a middle to low-income country. Our results demonstrated a comparable 1-year graft survival rate to high-income countries. 2024-06-06T09:50:48Z 2024-06-06T09:50:48Z 2023 2024-06-06T09:33:30Z Thesis / Dissertation Masters MMed http://hdl.handle.net/11427/39884 eng application/pdf Division of General Surgery Faculty of Health Sciences |
| spellingShingle | General Surgery Theron, Yolande Outcomes of penetrating keratoplasty at a tertiary institution in South Africa. |
| thesis_degree_str | Master's |
| title | Outcomes of penetrating keratoplasty at a tertiary institution in South Africa. |
| title_full | Outcomes of penetrating keratoplasty at a tertiary institution in South Africa. |
| title_fullStr | Outcomes of penetrating keratoplasty at a tertiary institution in South Africa. |
| title_full_unstemmed | Outcomes of penetrating keratoplasty at a tertiary institution in South Africa. |
| title_short | Outcomes of penetrating keratoplasty at a tertiary institution in South Africa. |
| title_sort | outcomes of penetrating keratoplasty at a tertiary institution in south africa |
| topic | General Surgery |
| url | http://hdl.handle.net/11427/39884 |
| work_keys_str_mv | AT theronyolande outcomesofpenetratingkeratoplastyatatertiaryinstitutioninsouthafrica |