Full Text Available

Access Repository
Note: Clicking the button above will open the full text document at the original institutional repository in a new window.
Cover Image

Ultrasonographic circumferential strain pattern analysis of the cardiac septal wall in rodents with experimental pulmonary hypertension.

Show other versions (1)

Pulmonary arterial hypertension (PAH) remains a devastating disease. Early diagnosis remains challenging, but is associated with improved outcomes. Rodent models have been extensively used to investigate PAH. Ultrasonographic strain pattern analysis provides a novel method of assessing cardiac funct...

Full description

Saved in:
Main Author: Van Heyningen, Charl
Other Authors: Swanevelder, Justiaan
Format: Thesis
Language:Eng
Published: Department of Anaesthesia and Perioperative Medicine 2024
Subjects:
Anaesthesia and Perioperative Medicine
Tags: Add Tag
No Tags, Be the first to tag this record!
_version_ 1867614336975896576
access_status_str Open Access
author Van Heyningen, Charl
author2 Swanevelder, Justiaan
author_browse Swanevelder, Justiaan
Van Heyningen, Charl
author_facet Swanevelder, Justiaan
Van Heyningen, Charl
author_sort Van Heyningen, Charl
collection Thesis
description Pulmonary arterial hypertension (PAH) remains a devastating disease. Early diagnosis remains challenging, but is associated with improved outcomes. Rodent models have been extensively used to investigate PAH. Ultrasonographic strain pattern analysis provides a novel method of assessing cardiac function, but difficulties in transthoracic imaging of the right heart are a barrier to its use in diagnosis of PAH. Segmental strain pattern analysis of the intraventricular septum circumvents this problem while still providing insight into right ventricular (RV) function. In this paper, the authors compare the septal strain pattern of rodents with chemically-induced PAH, to a known indicator of right heart pressures, pulmonary arterial acceleration time (PAAT). Method This was a secondary analysis of ultrasonographic data of rodents from a previous study with chemically-induced PAH. Strain pattern analysis was used to identify peak circumferential strain (CS) of the septal segment on short axis views via transthoracic echocardiography. PAAT was also measured. Regression analysis was performed to assess the relationship between the parameters. Results The relationship between CS and PAAT was linear (y = 7.1343 + -0.6118 x, p=0.001, R2 0.69). Rodents' predicted CS was equal to 0.59 + (-1.1 x PAATms). CS increased by 1.1% for every 1 ms decrease in PAAT. Conclusion In rodents with PAH, peak CS of the septal segment on short axis view can be used to predict PAAT, and thus be used as a measure of PAH. Peak CS can reliably and easily be measured using transthoracic echocardiography, and may be valuable in the investigation and management of PAH in humans. Further studies should be conducted.
format Thesis
id oai:open.uct.ac.za:11427/40174
institution University of Cape Town (South Africa)
language Eng
last_indexed 2026-06-10T12:50:26.125Z
license_str Not specified — see source repository
provenance_str_mv Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository
publishDate 2024
publishDateRange 2024
publishDateSort 2024
publisher Department of Anaesthesia and Perioperative Medicine
publisherStr Department of Anaesthesia and Perioperative Medicine
record_format dspace
source_str UCTD — University of Cape Town Open Access Repository
spelling oai:open.uct.ac.za:11427/40174 Ultrasonographic circumferential strain pattern analysis of the cardiac septal wall in rodents with experimental pulmonary hypertension. Van Heyningen, Charl Swanevelder, Justiaan Anaesthesia and Perioperative Medicine Pulmonary arterial hypertension (PAH) remains a devastating disease. Early diagnosis remains challenging, but is associated with improved outcomes. Rodent models have been extensively used to investigate PAH. Ultrasonographic strain pattern analysis provides a novel method of assessing cardiac function, but difficulties in transthoracic imaging of the right heart are a barrier to its use in diagnosis of PAH. Segmental strain pattern analysis of the intraventricular septum circumvents this problem while still providing insight into right ventricular (RV) function. In this paper, the authors compare the septal strain pattern of rodents with chemically-induced PAH, to a known indicator of right heart pressures, pulmonary arterial acceleration time (PAAT). Method This was a secondary analysis of ultrasonographic data of rodents from a previous study with chemically-induced PAH. Strain pattern analysis was used to identify peak circumferential strain (CS) of the septal segment on short axis views via transthoracic echocardiography. PAAT was also measured. Regression analysis was performed to assess the relationship between the parameters. Results The relationship between CS and PAAT was linear (y = 7.1343 + -0.6118 x, p=0.001, R2 0.69). Rodents' predicted CS was equal to 0.59 + (-1.1 x PAATms). CS increased by 1.1% for every 1 ms decrease in PAAT. Conclusion In rodents with PAH, peak CS of the septal segment on short axis view can be used to predict PAAT, and thus be used as a measure of PAH. Peak CS can reliably and easily be measured using transthoracic echocardiography, and may be valuable in the investigation and management of PAH in humans. Further studies should be conducted. 2024-07-02T10:09:57Z 2024-07-02T10:09:57Z 2023 2024-06-06T14:37:45Z Thesis / Dissertation Masters MMed http://hdl.handle.net/11427/40174 Eng application/pdf Department of Anaesthesia and Perioperative Medicine Faculty of Health Sciences
spellingShingle Anaesthesia and Perioperative Medicine
Van Heyningen, Charl
Ultrasonographic circumferential strain pattern analysis of the cardiac septal wall in rodents with experimental pulmonary hypertension.
thesis_degree_str Master's
title Ultrasonographic circumferential strain pattern analysis of the cardiac septal wall in rodents with experimental pulmonary hypertension.
title_full Ultrasonographic circumferential strain pattern analysis of the cardiac septal wall in rodents with experimental pulmonary hypertension.
title_fullStr Ultrasonographic circumferential strain pattern analysis of the cardiac septal wall in rodents with experimental pulmonary hypertension.
title_full_unstemmed Ultrasonographic circumferential strain pattern analysis of the cardiac septal wall in rodents with experimental pulmonary hypertension.
title_short Ultrasonographic circumferential strain pattern analysis of the cardiac septal wall in rodents with experimental pulmonary hypertension.
title_sort ultrasonographic circumferential strain pattern analysis of the cardiac septal wall in rodents with experimental pulmonary hypertension
topic Anaesthesia and Perioperative Medicine
url http://hdl.handle.net/11427/40174
work_keys_str_mv AT vanheyningencharl ultrasonographiccircumferentialstrainpatternanalysisofthecardiacseptalwallinrodentswithexperimentalpulmonaryhypertension

Similar Items