Full Text Available
Note: Clicking the button above will open the full text document at the original institutional repository in a new window.
The characterisation of hibernating myocardium : a study of imaging techniques, histological features and clinical relevance
Patients with impaired left ventricular function have a poor prognosis. Those with three vessel coronary artery disease who successfully undergo revascularisation have a better outlook but their peri-operative risk is high. Viable myocardium with impaired coronary flow reserve and impaired contracti...
Saved in:
| Main Author: | |
|---|---|
| Format: | Thesis |
| Language: | English |
| Published: |
Department of Medicine
2024
|
| Subjects: | |
| Tags: |
No Tags, Be the first to tag this record!
|
| _version_ | 1867613263418621952 |
|---|---|
| access_status_str | Open Access |
| author | Gunning, Mark Gerard |
| author_browse | Gunning, Mark Gerard |
| author_facet | Gunning, Mark Gerard |
| author_sort | Gunning, Mark Gerard |
| collection | Thesis |
| description | Patients with impaired left ventricular function have a poor prognosis. Those with three vessel coronary artery disease who successfully undergo revascularisation have a better outlook but their peri-operative risk is high. Viable myocardium with impaired coronary flow reserve and impaired contractility recovers function following revascularisation and the preoperative identification of this "hibernating myocardium" helps to select those patients most likely to benefit from surgery. The accurate differentiation of hibernating tissue from full thickness myocardial scar is important as the choice of the correct treatment for patients with or without evidence of hibernation has important prognostic implications. This work comprises five studies which evaluate the comparison of imaging techniques for the identification of myocardial hibernation, the histological features which characterise hibernating tissue when compared to normal myocardium or scar, and the relationship of histology to imaging characteristics, and finally the clinical impact of revascularising hibernating myocardium when compared with medical treatment alone. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/40260 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:33:21.255Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2024 |
| publishDateRange | 2024 |
| publishDateSort | 2024 |
| publisher | Department of Medicine |
| publisherStr | Department of Medicine |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/40260 The characterisation of hibernating myocardium : a study of imaging techniques, histological features and clinical relevance Gunning, Mark Gerard Medicine Patients with impaired left ventricular function have a poor prognosis. Those with three vessel coronary artery disease who successfully undergo revascularisation have a better outlook but their peri-operative risk is high. Viable myocardium with impaired coronary flow reserve and impaired contractility recovers function following revascularisation and the preoperative identification of this "hibernating myocardium" helps to select those patients most likely to benefit from surgery. The accurate differentiation of hibernating tissue from full thickness myocardial scar is important as the choice of the correct treatment for patients with or without evidence of hibernation has important prognostic implications. This work comprises five studies which evaluate the comparison of imaging techniques for the identification of myocardial hibernation, the histological features which characterise hibernating tissue when compared to normal myocardium or scar, and the relationship of histology to imaging characteristics, and finally the clinical impact of revascularising hibernating myocardium when compared with medical treatment alone. 2024-07-04T13:35:16Z 2024-07-04T13:35:16Z 1999 2024-07-04T12:50:11Z Thesis / Dissertation Doctoral MD http://hdl.handle.net/11427/40260 eng application/pdf Department of Medicine Faculty of Health Sciences |
| spellingShingle | Medicine Gunning, Mark Gerard The characterisation of hibernating myocardium : a study of imaging techniques, histological features and clinical relevance |
| thesis_degree_str | Doctoral |
| title | The characterisation of hibernating myocardium : a study of imaging techniques, histological features and clinical relevance |
| title_full | The characterisation of hibernating myocardium : a study of imaging techniques, histological features and clinical relevance |
| title_fullStr | The characterisation of hibernating myocardium : a study of imaging techniques, histological features and clinical relevance |
| title_full_unstemmed | The characterisation of hibernating myocardium : a study of imaging techniques, histological features and clinical relevance |
| title_short | The characterisation of hibernating myocardium : a study of imaging techniques, histological features and clinical relevance |
| title_sort | characterisation of hibernating myocardium a study of imaging techniques histological features and clinical relevance |
| topic | Medicine |
| url | http://hdl.handle.net/11427/40260 |
| work_keys_str_mv | AT gunningmarkgerard thecharacterisationofhibernatingmyocardiumastudyofimagingtechniqueshistologicalfeaturesandclinicalrelevance AT gunningmarkgerard characterisationofhibernatingmyocardiumastudyofimagingtechniqueshistologicalfeaturesandclinicalrelevance |