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Development and study of a monoclonal antibody to the human HLA-class II invariant chain
The work I present in this thesis was initiated by a request for a monoclonal antibody (MoAb) to the peripheral blood cells of a patient with chronic lymphocytic leukemia (CLL). It was initially hoped that such an antibody, if directed against an idiotypic determinant on the malignant B-cell surface...
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| Format: | Thesis |
| Language: | English |
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Department of Biological Sciences
2024
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| _version_ | 1867613188957143040 |
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| access_status_str | Open Access |
| author | Veenstra, Hannelore F U |
| author2 | Professor E.B. Dowdle |
| author_browse | Professor E.B. Dowdle Veenstra, Hannelore F U |
| author_facet | Professor E.B. Dowdle Veenstra, Hannelore F U |
| author_sort | Veenstra, Hannelore F U |
| collection | Thesis |
| description | The work I present in this thesis was initiated by a request for a monoclonal antibody (MoAb) to the peripheral blood cells of a patient with chronic lymphocytic leukemia (CLL). It was initially hoped that such an antibody, if directed against an idiotypic determinant on the malignant B-cell surface, may prove to be useful therapeutically by virtue of its specificity and limited reactivity. At the time at which the request was made there had already been favourable reports of the use of MoAb's for the management of B-cell derived malignancies |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/40516 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:32:11.035Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2024 |
| publishDateRange | 2024 |
| publishDateSort | 2024 |
| publisher | Department of Biological Sciences |
| publisherStr | Department of Biological Sciences |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/40516 Development and study of a monoclonal antibody to the human HLA-class II invariant chain Veenstra, Hannelore F U Professor E.B. Dowdle Antibodies The work I present in this thesis was initiated by a request for a monoclonal antibody (MoAb) to the peripheral blood cells of a patient with chronic lymphocytic leukemia (CLL). It was initially hoped that such an antibody, if directed against an idiotypic determinant on the malignant B-cell surface, may prove to be useful therapeutically by virtue of its specificity and limited reactivity. At the time at which the request was made there had already been favourable reports of the use of MoAb's for the management of B-cell derived malignancies 2024-08-16T13:11:48Z 2024-08-16T13:11:48Z 1991 2024-08-16T12:07:39Z Thesis / Dissertation Masters Masters http://hdl.handle.net/11427/40516 eng application/pdf Department of Biological Sciences Faculty of Science |
| spellingShingle | Antibodies Veenstra, Hannelore F U Development and study of a monoclonal antibody to the human HLA-class II invariant chain |
| thesis_degree_str | Master's |
| title | Development and study of a monoclonal antibody to the human HLA-class II invariant chain |
| title_full | Development and study of a monoclonal antibody to the human HLA-class II invariant chain |
| title_fullStr | Development and study of a monoclonal antibody to the human HLA-class II invariant chain |
| title_full_unstemmed | Development and study of a monoclonal antibody to the human HLA-class II invariant chain |
| title_short | Development and study of a monoclonal antibody to the human HLA-class II invariant chain |
| title_sort | development and study of a monoclonal antibody to the human hla class ii invariant chain |
| topic | Antibodies |
| url | http://hdl.handle.net/11427/40516 |
| work_keys_str_mv | AT veenstrahannelorefu developmentandstudyofamonoclonalantibodytothehumanhlaclassiiinvariantchain |