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Differentially expressed genes in oesophageal cancer
Oesophageal cancer (OC) is a leading cause of cancer death in the black population in South Africa. The lifetime risk of the disease amongst black males is 1 in 59. High incidence areas are the Transkei, Ciskei and KwaZulu-Natal where it is responsible for over 45 of all malignancies. Cancer develop...
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| Format: | Thesis |
| Language: | English |
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Division of Medical Biochemistry
2024
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| _version_ | 1867613284049354753 |
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| access_status_str | Open Access |
| author | Wamunyokoli, Fred Alexander Wafula |
| author2 | Parker, Iqbal |
| author_browse | Parker, Iqbal Wamunyokoli, Fred Alexander Wafula |
| author_facet | Parker, Iqbal Wamunyokoli, Fred Alexander Wafula |
| author_sort | Wamunyokoli, Fred Alexander Wafula |
| collection | Thesis |
| description | Oesophageal cancer (OC) is a leading cause of cancer death in the black population in South Africa. The lifetime risk of the disease amongst black males is 1 in 59. High incidence areas are the Transkei, Ciskei and KwaZulu-Natal where it is responsible for over 45 of all malignancies. Cancer develops through a multistep process of genomic instability of clonal evolution. Several oncogenes, tumour suppressor genes and transcription factors have been shown to be altered in oesophageal cancer. Their role however, in the development and/or susceptibility to the development of oesophageal cancer is poorly understood. The aim if this project is to identify candidate genes that are differentially expressed in oesophageal cancer patients with a view to understanding the development of oesophageal cancer. The ultimate objective of the project is to use this data to develop possible biomarkers for the disease. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/40709 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:33:41.762Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2024 |
| publishDateRange | 2024 |
| publishDateSort | 2024 |
| publisher | Division of Medical Biochemistry |
| publisherStr | Division of Medical Biochemistry |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/40709 Differentially expressed genes in oesophageal cancer Wamunyokoli, Fred Alexander Wafula Parker, Iqbal Hendricks, Denver T Medical Biochemistry Oesophageal cancer (OC) is a leading cause of cancer death in the black population in South Africa. The lifetime risk of the disease amongst black males is 1 in 59. High incidence areas are the Transkei, Ciskei and KwaZulu-Natal where it is responsible for over 45 of all malignancies. Cancer develops through a multistep process of genomic instability of clonal evolution. Several oncogenes, tumour suppressor genes and transcription factors have been shown to be altered in oesophageal cancer. Their role however, in the development and/or susceptibility to the development of oesophageal cancer is poorly understood. The aim if this project is to identify candidate genes that are differentially expressed in oesophageal cancer patients with a view to understanding the development of oesophageal cancer. The ultimate objective of the project is to use this data to develop possible biomarkers for the disease. 2024-11-15T10:08:29Z 2024-11-15T10:08:29Z 2002 2024-08-13T14:18:53Z Thesis / Dissertation Doctoral PhD http://hdl.handle.net/11427/40709 eng application/pdf Division of Medical Biochemistry Faculty of Health Sciences University of Cape Town |
| spellingShingle | Medical Biochemistry Wamunyokoli, Fred Alexander Wafula Differentially expressed genes in oesophageal cancer |
| thesis_degree_str | Doctoral |
| title | Differentially expressed genes in oesophageal cancer |
| title_full | Differentially expressed genes in oesophageal cancer |
| title_fullStr | Differentially expressed genes in oesophageal cancer |
| title_full_unstemmed | Differentially expressed genes in oesophageal cancer |
| title_short | Differentially expressed genes in oesophageal cancer |
| title_sort | differentially expressed genes in oesophageal cancer |
| topic | Medical Biochemistry |
| url | http://hdl.handle.net/11427/40709 |
| work_keys_str_mv | AT wamunyokolifredalexanderwafula differentiallyexpressedgenesinoesophagealcancer |