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In vitro metabolism studies to inform physiologically-based pharmacokinetic modelling of mefloquine, ritonavir and proguanil
Clinically observed variability in drug exposure has various negative implications, ranging from an increased possibility of adverse drug reactions to treatment failure. A key contributor to this variability is the contribution of drug metabolism, substantially mediated by the cytochrome P450 (CYP)...
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| Format: | Thesis |
| Language: | English |
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Department of Chemistry
2025
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