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The intersection of the HIV epidemic and blood donation in South Africa
South Africa's large population of people living with HIV (PLWH) affects the local blood transfusion services (BTS) in multiple ways, including the recruitment of safe donors, the demand for blood and the development of blood safety policies. The latter includes the deferral of persons at risk of re...
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| Format: | Thesis |
| Language: | English ENG |
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Department of Medicine
2025
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| _version_ | 1867613312258146304 |
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| access_status_str | Open Access |
| author | Van Den Berg, Karin |
| author2 | Louw, Vernon |
| author_browse | Louw, Vernon Van Den Berg, Karin |
| author_facet | Louw, Vernon Van Den Berg, Karin |
| author_sort | Van Den Berg, Karin |
| collection | Thesis |
| description | South Africa's large population of people living with HIV (PLWH) affects the local blood transfusion services (BTS) in multiple ways, including the recruitment of safe donors, the demand for blood and the development of blood safety policies. The latter includes the deferral of persons at risk of recently acquired HIV and sensitive testing for HIV antibodies and RNA. Estimating HIV incidence in blood donors is a key measure of successful prevention strategies. Blood donation by PLWH on antiretroviral therapy (ART) was identified as an emerging risk to blood safety as early ART initiation may result in delayed seroconversion, seroreversion, and prolonged suppression of viral replication which may escape detection by HIV antibody and nucleic acid amplification testing (NAT). My PhD research used epidemiologic, incidence modelling and mixed-method qualitative research techniques to assess the impact of undisclosed ART use among blood donors on the safety of the country's blood supply. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/41294 |
| institution | University of Cape Town (South Africa) |
| language | English ENG |
| last_indexed | 2026-06-10T12:34:08.683Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2025 |
| publishDateRange | 2025 |
| publishDateSort | 2025 |
| publisher | Department of Medicine |
| publisherStr | Department of Medicine |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/41294 The intersection of the HIV epidemic and blood donation in South Africa Van Den Berg, Karin Louw, Vernon Maartens, Gary Murphy, Edward Hughes, Shana HIV Blood donation South Africa's large population of people living with HIV (PLWH) affects the local blood transfusion services (BTS) in multiple ways, including the recruitment of safe donors, the demand for blood and the development of blood safety policies. The latter includes the deferral of persons at risk of recently acquired HIV and sensitive testing for HIV antibodies and RNA. Estimating HIV incidence in blood donors is a key measure of successful prevention strategies. Blood donation by PLWH on antiretroviral therapy (ART) was identified as an emerging risk to blood safety as early ART initiation may result in delayed seroconversion, seroreversion, and prolonged suppression of viral replication which may escape detection by HIV antibody and nucleic acid amplification testing (NAT). My PhD research used epidemiologic, incidence modelling and mixed-method qualitative research techniques to assess the impact of undisclosed ART use among blood donors on the safety of the country's blood supply. 2025-03-31T07:33:45Z 2025-03-31T07:33:45Z 2024 2025-03-31T07:28:30Z Thesis / Dissertation Doctoral PhD http://hdl.handle.net/11427/41294 en ENG application/pdf Department of Medicine Faculty of Health Sciences University of Cape Town |
| spellingShingle | HIV Blood donation Van Den Berg, Karin The intersection of the HIV epidemic and blood donation in South Africa |
| thesis_degree_str | Doctoral |
| title | The intersection of the HIV epidemic and blood donation in South Africa |
| title_full | The intersection of the HIV epidemic and blood donation in South Africa |
| title_fullStr | The intersection of the HIV epidemic and blood donation in South Africa |
| title_full_unstemmed | The intersection of the HIV epidemic and blood donation in South Africa |
| title_short | The intersection of the HIV epidemic and blood donation in South Africa |
| title_sort | intersection of the hiv epidemic and blood donation in south africa |
| topic | HIV Blood donation |
| url | http://hdl.handle.net/11427/41294 |
| work_keys_str_mv | AT vandenbergkarin theintersectionofthehivepidemicandblooddonationinsouthafrica AT vandenbergkarin intersectionofthehivepidemicandblooddonationinsouthafrica |