Full Text Available
Note: Clicking the button above will open the full text document at the original institutional repository in a new window.
Population pharmacokinetic modelling to optimise treatment for children with Rifampicin-resistant TB and HIV
The global burden of rifampicin- and/or multidrug-resistant (RR/MDR) -TB, i.e. Mycobacterium tuberculosis resistant to rifampicin and/or isoniazid is increasing, especially in settings with high HIV prevalence. Optimising the prevention and treatment of RR/MDR-TB in children in such settings is crit...
Saved in:
| Main Author: | |
|---|---|
| Other Authors: | |
| Format: | Thesis |
| Language: | English ENG |
| Published: |
Department of Medicine
2025
|
| Subjects: | |
| Tags: |
No Tags, Be the first to tag this record!
|
| _version_ | 1867613234694979584 |
|---|---|
| access_status_str | Open Access |
| author | Van der Laan, Louvina Elizabeth |
| author2 | Denti, Paolo |
| author_browse | Denti, Paolo Van der Laan, Louvina Elizabeth |
| author_facet | Denti, Paolo Van der Laan, Louvina Elizabeth |
| author_sort | Van der Laan, Louvina Elizabeth |
| collection | Thesis |
| description | The global burden of rifampicin- and/or multidrug-resistant (RR/MDR) -TB, i.e. Mycobacterium tuberculosis resistant to rifampicin and/or isoniazid is increasing, especially in settings with high HIV prevalence. Optimising the prevention and treatment of RR/MDR-TB in children in such settings is critically important. Population pharmacokinetic modelling, the state-of-the art technique to interpret pharmacological data, can play a pivotal role for therapeutic optimization in children, since it enables characterisation and inclusion of the effects of important developmental factors, thus allowing for determination and evaluation of effective yet safe RR/MDR treatment in children. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/41299 |
| institution | University of Cape Town (South Africa) |
| language | English ENG |
| last_indexed | 2026-06-10T12:32:54.720Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2025 |
| publishDateRange | 2025 |
| publishDateSort | 2025 |
| publisher | Department of Medicine |
| publisherStr | Department of Medicine |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/41299 Population pharmacokinetic modelling to optimise treatment for children with Rifampicin-resistant TB and HIV Van der Laan, Louvina Elizabeth Denti, Paolo Hesseling, Anneke Garcia-Prats, Anthony Rifampicin-resistant TB HIV The global burden of rifampicin- and/or multidrug-resistant (RR/MDR) -TB, i.e. Mycobacterium tuberculosis resistant to rifampicin and/or isoniazid is increasing, especially in settings with high HIV prevalence. Optimising the prevention and treatment of RR/MDR-TB in children in such settings is critically important. Population pharmacokinetic modelling, the state-of-the art technique to interpret pharmacological data, can play a pivotal role for therapeutic optimization in children, since it enables characterisation and inclusion of the effects of important developmental factors, thus allowing for determination and evaluation of effective yet safe RR/MDR treatment in children. 2025-03-31T07:58:36Z 2025-03-31T07:58:36Z 2024 2025-03-31T07:56:43Z Thesis / Dissertation Doctoral PhD http://hdl.handle.net/11427/41299 en ENG application/pdf Department of Medicine Faculty of Health Sciences University of Cape Town |
| spellingShingle | Rifampicin-resistant TB HIV Van der Laan, Louvina Elizabeth Population pharmacokinetic modelling to optimise treatment for children with Rifampicin-resistant TB and HIV |
| thesis_degree_str | Doctoral |
| title | Population pharmacokinetic modelling to optimise treatment for children with Rifampicin-resistant TB and HIV |
| title_full | Population pharmacokinetic modelling to optimise treatment for children with Rifampicin-resistant TB and HIV |
| title_fullStr | Population pharmacokinetic modelling to optimise treatment for children with Rifampicin-resistant TB and HIV |
| title_full_unstemmed | Population pharmacokinetic modelling to optimise treatment for children with Rifampicin-resistant TB and HIV |
| title_short | Population pharmacokinetic modelling to optimise treatment for children with Rifampicin-resistant TB and HIV |
| title_sort | population pharmacokinetic modelling to optimise treatment for children with rifampicin resistant tb and hiv |
| topic | Rifampicin-resistant TB HIV |
| url | http://hdl.handle.net/11427/41299 |
| work_keys_str_mv | AT vanderlaanlouvinaelizabeth populationpharmacokineticmodellingtooptimisetreatmentforchildrenwithrifampicinresistanttbandhiv |