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Bone Mineral Density In Hiv: A Comparison Of Hiv Positive Versus Negative Patient With Lower Limb Long Bone Fractures
Background: Osteoporosis is a global health issue causing a deterioration in bone microarchitecture, compromising bone strength. In South Africa (SA), the prevalence of osteoporosis is a growing concern for both HIV-positive and HIVnegative individuals. The aim of this study was to assess the impact...
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| Format: | Thesis |
| Language: | Eng |
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Division of General Surgery
2025
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| _version_ | 1867613152792805376 |
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| access_status_str | Open Access |
| author | Botha, Peter |
| author2 | Laubscher, Maritz |
| author_browse | Botha, Peter Laubscher, Maritz |
| author_facet | Laubscher, Maritz Botha, Peter |
| author_sort | Botha, Peter |
| collection | Thesis |
| description | Background: Osteoporosis is a global health issue causing a deterioration in bone microarchitecture, compromising bone strength. In South Africa (SA), the prevalence of osteoporosis is a growing concern for both HIV-positive and HIVnegative individuals. The aim of this study was to assess the impact of HIV infection on bone mineral density (BMD) in HIV-positive individuals and compare this to the BMD in HIV-negative individuals with traumatic long-bone fractures. In addition, we compared the impact of demographics, nutritional (albumin), Vitamin D status and smoking between HIV-positive and negative individuals. Patients and Methods: We retrospectively reviewed data from a prospectively collected database within the HIV in Orthopaedic Skeletal Trauma (HOST) study conducted at tertiary care hospitals. This study included all individuals with a confirmed HIV positive or negative status who had their BMD measurement performed using a calcaneal quantitative ultrasound scan (cQUS) and excluded those individuals who had never had a cQUS performed. Results: Of 400 individuals recruited from the parent study, 172 (43%) had their BMD measured. 27(15.7%) were HIV-positive. Overall, the BMD and T-scores were similar in both the HIV-positive and HIV-negative participants with a median BMD of 0.49 g/cm2 (0.23 – 0.71) within the HIV positive group; 0.49 (0.3-0.71) within the HIV negative group and an overall T-score of -0.8, with no statistical significance found between the two groups (p>0.050). Age, smoking status, Vitamin D, Albumin and BMI had no effect on BMD (p> 0.050). Conclusion: We found a higher proportion of patients with osteoporosis within the HIV-positive cohort, although not statistically significant and no statistically significant difference in the median BMD between the HIV -positive and HIVnegative subgroups. Neither age, smoking, vitamin D, albumin nor BMI was associated with a lower BMD |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/41486 |
| institution | University of Cape Town (South Africa) |
| language | Eng |
| last_indexed | 2026-06-10T12:31:35.974Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2025 |
| publishDateRange | 2025 |
| publishDateSort | 2025 |
| publisher | Division of General Surgery |
| publisherStr | Division of General Surgery |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/41486 Bone Mineral Density In Hiv: A Comparison Of Hiv Positive Versus Negative Patient With Lower Limb Long Bone Fractures Botha, Peter Laubscher, Maritz Maqungo Sithombo General Surgery Background: Osteoporosis is a global health issue causing a deterioration in bone microarchitecture, compromising bone strength. In South Africa (SA), the prevalence of osteoporosis is a growing concern for both HIV-positive and HIVnegative individuals. The aim of this study was to assess the impact of HIV infection on bone mineral density (BMD) in HIV-positive individuals and compare this to the BMD in HIV-negative individuals with traumatic long-bone fractures. In addition, we compared the impact of demographics, nutritional (albumin), Vitamin D status and smoking between HIV-positive and negative individuals. Patients and Methods: We retrospectively reviewed data from a prospectively collected database within the HIV in Orthopaedic Skeletal Trauma (HOST) study conducted at tertiary care hospitals. This study included all individuals with a confirmed HIV positive or negative status who had their BMD measurement performed using a calcaneal quantitative ultrasound scan (cQUS) and excluded those individuals who had never had a cQUS performed. Results: Of 400 individuals recruited from the parent study, 172 (43%) had their BMD measured. 27(15.7%) were HIV-positive. Overall, the BMD and T-scores were similar in both the HIV-positive and HIV-negative participants with a median BMD of 0.49 g/cm2 (0.23 – 0.71) within the HIV positive group; 0.49 (0.3-0.71) within the HIV negative group and an overall T-score of -0.8, with no statistical significance found between the two groups (p>0.050). Age, smoking status, Vitamin D, Albumin and BMI had no effect on BMD (p> 0.050). Conclusion: We found a higher proportion of patients with osteoporosis within the HIV-positive cohort, although not statistically significant and no statistically significant difference in the median BMD between the HIV -positive and HIVnegative subgroups. Neither age, smoking, vitamin D, albumin nor BMI was associated with a lower BMD 2025-06-25T11:51:10Z 2025-06-25T11:51:10Z 2025 2025-06-25T11:47:27Z Thesis / Dissertation Masters MMed http://hdl.handle.net/11427/41486 Eng application/pdf Division of General Surgery Faculty of Health Sciences University of Cape town |
| spellingShingle | General Surgery Botha, Peter Bone Mineral Density In Hiv: A Comparison Of Hiv Positive Versus Negative Patient With Lower Limb Long Bone Fractures |
| thesis_degree_str | Master's |
| title | Bone Mineral Density In Hiv: A Comparison Of Hiv Positive Versus Negative Patient With Lower Limb Long Bone Fractures |
| title_full | Bone Mineral Density In Hiv: A Comparison Of Hiv Positive Versus Negative Patient With Lower Limb Long Bone Fractures |
| title_fullStr | Bone Mineral Density In Hiv: A Comparison Of Hiv Positive Versus Negative Patient With Lower Limb Long Bone Fractures |
| title_full_unstemmed | Bone Mineral Density In Hiv: A Comparison Of Hiv Positive Versus Negative Patient With Lower Limb Long Bone Fractures |
| title_short | Bone Mineral Density In Hiv: A Comparison Of Hiv Positive Versus Negative Patient With Lower Limb Long Bone Fractures |
| title_sort | bone mineral density in hiv a comparison of hiv positive versus negative patient with lower limb long bone fractures |
| topic | General Surgery |
| url | http://hdl.handle.net/11427/41486 |
| work_keys_str_mv | AT bothapeter bonemineraldensityinhivacomparisonofhivpositiveversusnegativepatientwithlowerlimblongbonefractures |