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The immunomodulatory role of prednisone in patients with HIV-associated tuberculosis and assessment of its impact on lung function outcome
In this thesis, I assess the effect of prednisone on immunopathology and pulmonary function in HIV-associated tuberculosis and tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS). I do this using data collected during the PredART trial. This randomized, double-blind, placeb...
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| Format: | Thesis |
| Language: | English |
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Department of Medicine
2025
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| _version_ | 1867613239905353728 |
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| access_status_str | Open Access |
| author | Stek, Cari |
| author2 | Meintjes, Graeme |
| author_browse | Meintjes, Graeme Stek, Cari |
| author_facet | Meintjes, Graeme Stek, Cari |
| author_sort | Stek, Cari |
| collection | Thesis |
| description | In this thesis, I assess the effect of prednisone on immunopathology and pulmonary function in HIV-associated tuberculosis and tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS). I do this using data collected during the PredART trial. This randomized, double-blind, placebo-controlled trial showed that a 28-day course of prophylactic prednisone in adult patients identified as being at high risk for paradoxical TB-IRIS reduced the incidence of paradoxical TB-IRIS by 30%, without an excess of adverse events. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/41559 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:32:58.612Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2025 |
| publishDateRange | 2025 |
| publishDateSort | 2025 |
| publisher | Department of Medicine |
| publisherStr | Department of Medicine |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/41559 The immunomodulatory role of prednisone in patients with HIV-associated tuberculosis and assessment of its impact on lung function outcome Stek, Cari Meintjes, Graeme Shey Muki lung function In this thesis, I assess the effect of prednisone on immunopathology and pulmonary function in HIV-associated tuberculosis and tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS). I do this using data collected during the PredART trial. This randomized, double-blind, placebo-controlled trial showed that a 28-day course of prophylactic prednisone in adult patients identified as being at high risk for paradoxical TB-IRIS reduced the incidence of paradoxical TB-IRIS by 30%, without an excess of adverse events. 2025-08-08T11:25:34Z 2025-08-08T11:25:34Z 2022 2025-08-08T11:23:51Z Thesis / Dissertation Doctoral PhD http://hdl.handle.net/11427/41559 eng application/pdf Department of Medicine Faculty of Health Sciences |
| spellingShingle | lung function Stek, Cari The immunomodulatory role of prednisone in patients with HIV-associated tuberculosis and assessment of its impact on lung function outcome |
| thesis_degree_str | Doctoral |
| title | The immunomodulatory role of prednisone in patients with HIV-associated tuberculosis and assessment of its impact on lung function outcome |
| title_full | The immunomodulatory role of prednisone in patients with HIV-associated tuberculosis and assessment of its impact on lung function outcome |
| title_fullStr | The immunomodulatory role of prednisone in patients with HIV-associated tuberculosis and assessment of its impact on lung function outcome |
| title_full_unstemmed | The immunomodulatory role of prednisone in patients with HIV-associated tuberculosis and assessment of its impact on lung function outcome |
| title_short | The immunomodulatory role of prednisone in patients with HIV-associated tuberculosis and assessment of its impact on lung function outcome |
| title_sort | immunomodulatory role of prednisone in patients with hiv associated tuberculosis and assessment of its impact on lung function outcome |
| topic | lung function |
| url | http://hdl.handle.net/11427/41559 |
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