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Biomarkers for autoimmunie disease diagnosis in the public health sector: A systematic review and meta-analysis
Rheumatic heart disease (RHD), rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) are autoimmune diseases with drastic effects on quality of life. Diagnostic challenges remain, especially given the prevalence of these diseases among people of low socioeconomic status. The purpose of th...
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| Format: | Thesis |
| Language: | English English |
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Department of Public Health and Family Medicine
2025
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| _version_ | 1867613237308030976 |
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| access_status_str | Open Access |
| author | Morar, Zeena |
| author2 | Engel, Mark |
| author_browse | Engel, Mark Morar, Zeena |
| author_facet | Engel, Mark Morar, Zeena |
| author_sort | Morar, Zeena |
| collection | Thesis |
| description | Rheumatic heart disease (RHD), rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) are autoimmune diseases with drastic effects on quality of life. Diagnostic challenges remain, especially given the prevalence of these diseases among people of low socioeconomic status. The purpose of this review was to determine, from published case-control and cross-sectional studies, whether selected protein biomarkers are discriminatory indicators of RHD, RA and SLE. This review was carried out in accordance with the Preferential Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA). A significant increase in adiponectin was found in patients with SLE and in patients with RA (including those with severe and mild cases of RA) as compared with healthy controls. Ficolin-3 was significantly upregulated in SLE patients and downregulated in RHD patients, while alpha-2-glycoprotein 1 was significantly upregulated in SLE patients compared to controls. Gelsolin was significantly downregulated in patients with RHD and in SLE patients with a flare-up and in remission. Given that data remain scant, further research into these proteins, along with others not previously identified, is warranted to evaluate their discriminatory power for the development of a cost-effective point-of-care diagnostic test. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/41805 |
| institution | University of Cape Town (South Africa) |
| language | English eng |
| last_indexed | 2026-06-10T12:32:57.328Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2025 |
| publishDateRange | 2025 |
| publishDateSort | 2025 |
| publisher | Department of Public Health and Family Medicine |
| publisherStr | Department of Public Health and Family Medicine |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/41805 Biomarkers for autoimmunie disease diagnosis in the public health sector: A systematic review and meta-analysis Morar, Zeena Engel, Mark Salie, Taariq Bana, Tasnim Rheumatic heart disease (RHD) Rheumatoid arthritis (RA) Systemic lupus erythematosus (SLE) Rheumatic heart disease (RHD), rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) are autoimmune diseases with drastic effects on quality of life. Diagnostic challenges remain, especially given the prevalence of these diseases among people of low socioeconomic status. The purpose of this review was to determine, from published case-control and cross-sectional studies, whether selected protein biomarkers are discriminatory indicators of RHD, RA and SLE. This review was carried out in accordance with the Preferential Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA). A significant increase in adiponectin was found in patients with SLE and in patients with RA (including those with severe and mild cases of RA) as compared with healthy controls. Ficolin-3 was significantly upregulated in SLE patients and downregulated in RHD patients, while alpha-2-glycoprotein 1 was significantly upregulated in SLE patients compared to controls. Gelsolin was significantly downregulated in patients with RHD and in SLE patients with a flare-up and in remission. Given that data remain scant, further research into these proteins, along with others not previously identified, is warranted to evaluate their discriminatory power for the development of a cost-effective point-of-care diagnostic test. 2025-09-15T09:56:48Z 2025-09-15T09:56:48Z 2025 2025-09-15T09:43:59Z Thesis / Dissertation Masters MPH http://hdl.handle.net/11427/41805 en eng application/pdf Department of Public Health and Family Medicine Faculty of Health Sciences University of Cape Town |
| spellingShingle | Rheumatic heart disease (RHD) Rheumatoid arthritis (RA) Systemic lupus erythematosus (SLE) Morar, Zeena Biomarkers for autoimmunie disease diagnosis in the public health sector: A systematic review and meta-analysis |
| thesis_degree_str | Master's |
| title | Biomarkers for autoimmunie disease diagnosis in the public health sector: A systematic review and meta-analysis |
| title_full | Biomarkers for autoimmunie disease diagnosis in the public health sector: A systematic review and meta-analysis |
| title_fullStr | Biomarkers for autoimmunie disease diagnosis in the public health sector: A systematic review and meta-analysis |
| title_full_unstemmed | Biomarkers for autoimmunie disease diagnosis in the public health sector: A systematic review and meta-analysis |
| title_short | Biomarkers for autoimmunie disease diagnosis in the public health sector: A systematic review and meta-analysis |
| title_sort | biomarkers for autoimmunie disease diagnosis in the public health sector a systematic review and meta analysis |
| topic | Rheumatic heart disease (RHD) Rheumatoid arthritis (RA) Systemic lupus erythematosus (SLE) |
| url | http://hdl.handle.net/11427/41805 |
| work_keys_str_mv | AT morarzeena biomarkersforautoimmuniediseasediagnosisinthepublichealthsectorasystematicreviewandmetaanalysis |