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Probing the mechanisms of action and resistance of mixed-ligand platinum(II) complexes with dual-stage antiplasmodium activity
Malaria remains one of the largest parasitic disease burdens worldwide, with the vast majority of that burden occurring on the African continent. The ongoing high number of malaria cases and deaths is in part attributable to the emergence and spread of resistance to most clinical chemotherapeutics....
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| Format: | Thesis |
| Language: | English |
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Department of Chemistry
2025
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| _version_ | 1867613252980047872 |
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| access_status_str | Open Access |
| author | Ishmail, Fatima-Zahra |
| author2 | Chibale, Kelly |
| author_browse | Chibale, Kelly Ishmail, Fatima-Zahra |
| author_facet | Chibale, Kelly Ishmail, Fatima-Zahra |
| author_sort | Ishmail, Fatima-Zahra |
| collection | Thesis |
| description | Malaria remains one of the largest parasitic disease burdens worldwide, with the vast majority of that burden occurring on the African continent. The ongoing high number of malaria cases and deaths is in part attributable to the emergence and spread of resistance to most clinical chemotherapeutics. With the reported development of partial resistance to the current front-line artemisinin-based combination therapies, there is an increased risk of malaria morbidity and mortality as limited replacement treatments are currently available. For that reason, it is essential to invest in the discovery of compounds with novel mechanisms of action (MoA), dual-stage activity, and with immutable targets. Until now, drug discovery has typically focused on the development of antimalarials that are entirely organic in composition. This has left the field of inorganic medicinal chemistry and transition metal-based chemotherapeutics underexplored and underrepresented. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/41857 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:33:12.104Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2025 |
| publishDateRange | 2025 |
| publishDateSort | 2025 |
| publisher | Department of Chemistry |
| publisherStr | Department of Chemistry |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/41857 Probing the mechanisms of action and resistance of mixed-ligand platinum(II) complexes with dual-stage antiplasmodium activity Ishmail, Fatima-Zahra Chibale, Kelly Wicht, Kathryn Woodland, John Egan, Timothy Malaria parasitic disease African Malaria remains one of the largest parasitic disease burdens worldwide, with the vast majority of that burden occurring on the African continent. The ongoing high number of malaria cases and deaths is in part attributable to the emergence and spread of resistance to most clinical chemotherapeutics. With the reported development of partial resistance to the current front-line artemisinin-based combination therapies, there is an increased risk of malaria morbidity and mortality as limited replacement treatments are currently available. For that reason, it is essential to invest in the discovery of compounds with novel mechanisms of action (MoA), dual-stage activity, and with immutable targets. Until now, drug discovery has typically focused on the development of antimalarials that are entirely organic in composition. This has left the field of inorganic medicinal chemistry and transition metal-based chemotherapeutics underexplored and underrepresented. 2025-09-18T10:30:10Z 2025-09-18T10:30:10Z 2025 2025-08-18T13:31:41Z Thesis / Dissertation Doctoral PhD http://hdl.handle.net/11427/41857 eng application/pdf Department of Chemistry Faculty of Science Universiy of Cape Town |
| spellingShingle | Malaria parasitic disease African Ishmail, Fatima-Zahra Probing the mechanisms of action and resistance of mixed-ligand platinum(II) complexes with dual-stage antiplasmodium activity |
| thesis_degree_str | Doctoral |
| title | Probing the mechanisms of action and resistance of mixed-ligand platinum(II) complexes with dual-stage antiplasmodium activity |
| title_full | Probing the mechanisms of action and resistance of mixed-ligand platinum(II) complexes with dual-stage antiplasmodium activity |
| title_fullStr | Probing the mechanisms of action and resistance of mixed-ligand platinum(II) complexes with dual-stage antiplasmodium activity |
| title_full_unstemmed | Probing the mechanisms of action and resistance of mixed-ligand platinum(II) complexes with dual-stage antiplasmodium activity |
| title_short | Probing the mechanisms of action and resistance of mixed-ligand platinum(II) complexes with dual-stage antiplasmodium activity |
| title_sort | probing the mechanisms of action and resistance of mixed ligand platinum ii complexes with dual stage antiplasmodium activity |
| topic | Malaria parasitic disease African |
| url | http://hdl.handle.net/11427/41857 |
| work_keys_str_mv | AT ishmailfatimazahra probingthemechanismsofactionandresistanceofmixedligandplatinumiicomplexeswithdualstageantiplasmodiumactivity |