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Prevalence of babies born with neural tube defects and geospatial mapping of therapeutic services: a systematic review
Introduction: Neural tube defects (NTDs) are an important global health concern with high morbidity and mortality. Enhancing access to healthcare for children born with NTDs is crucial for improving health systems and service delivery. Methods: We conducted a systematic review to assess the global p...
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| Format: | Thesis |
| Language: | English English |
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Division of General Surgery
2025
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| _version_ | 1867614399290671104 |
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| access_status_str | Open Access |
| author | Zolo Ossou, Andre Yvan |
| author2 | Maswime, Salome |
| author_browse | Maswime, Salome Zolo Ossou, Andre Yvan |
| author_facet | Maswime, Salome Zolo Ossou, Andre Yvan |
| author_sort | Zolo Ossou, Andre Yvan |
| collection | Thesis |
| description | Introduction: Neural tube defects (NTDs) are an important global health concern with high morbidity and mortality. Enhancing access to healthcare for children born with NTDs is crucial for improving health systems and service delivery. Methods: We conducted a systematic review to assess the global prevalence of NTDs and the accessibility of healthcare services. Our search spanned databases like PubMed, EMBASE, and Scopus, focusing on NTD prevalence, healthcare service mapping, and access barriers. We followed a standardized data extraction process, and the study is registered with PROSPERO (CRD42023425843). Results: From 3 067 records, 65 studies met our inclusion criteria, mainly focusing on newborns. The study durations range from six months to 40 years. The NTD prevalence was between 0.4 and 215.13 per 10 000 births, with Spina Bifida, Anencephaly, and Encephalocele being the most common. The African Region was the WHO region with the highest prevalence while the Western Pacific Region had the lowest prevalence. One study used geospatial mapping to identify healthcare access barriers. Conclusion: Our study revealed wide disparities in the prevalence rates of neural tube defects with the African region having the highest prevalence. Geospatial mapping was not used to assess access to healthcare services for children born with NTDs in almost all the studies. This underscores the global challenge of access to surgical care for children born with NTDs and the need for strengthening healthcare services in settings with high prevalences. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/41932 |
| institution | University of Cape Town (South Africa) |
| language | English eng |
| last_indexed | 2026-06-10T12:51:25.554Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2025 |
| publishDateRange | 2025 |
| publishDateSort | 2025 |
| publisher | Division of General Surgery |
| publisherStr | Division of General Surgery |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/41932 Prevalence of babies born with neural tube defects and geospatial mapping of therapeutic services: a systematic review Zolo Ossou, Andre Yvan Maswime, Salome Isiagi, Moses Accessibility of Healthcare Geospatial Mapping Healthcare Disparities Neural Tube Defects Policy Reform Introduction: Neural tube defects (NTDs) are an important global health concern with high morbidity and mortality. Enhancing access to healthcare for children born with NTDs is crucial for improving health systems and service delivery. Methods: We conducted a systematic review to assess the global prevalence of NTDs and the accessibility of healthcare services. Our search spanned databases like PubMed, EMBASE, and Scopus, focusing on NTD prevalence, healthcare service mapping, and access barriers. We followed a standardized data extraction process, and the study is registered with PROSPERO (CRD42023425843). Results: From 3 067 records, 65 studies met our inclusion criteria, mainly focusing on newborns. The study durations range from six months to 40 years. The NTD prevalence was between 0.4 and 215.13 per 10 000 births, with Spina Bifida, Anencephaly, and Encephalocele being the most common. The African Region was the WHO region with the highest prevalence while the Western Pacific Region had the lowest prevalence. One study used geospatial mapping to identify healthcare access barriers. Conclusion: Our study revealed wide disparities in the prevalence rates of neural tube defects with the African region having the highest prevalence. Geospatial mapping was not used to assess access to healthcare services for children born with NTDs in almost all the studies. This underscores the global challenge of access to surgical care for children born with NTDs and the need for strengthening healthcare services in settings with high prevalences. 2025-10-01T11:42:41Z 2025-10-01T11:42:41Z 2025 2025-10-01T11:40:34Z Thesis / Dissertation Masters MSc http://hdl.handle.net/11427/41932 en eng application/pdf Division of General Surgery Faculty of Health Sciences University of Cape Town |
| spellingShingle | Accessibility of Healthcare Geospatial Mapping Healthcare Disparities Neural Tube Defects Policy Reform Zolo Ossou, Andre Yvan Prevalence of babies born with neural tube defects and geospatial mapping of therapeutic services: a systematic review |
| thesis_degree_str | Master's |
| title | Prevalence of babies born with neural tube defects and geospatial mapping of therapeutic services: a systematic review |
| title_full | Prevalence of babies born with neural tube defects and geospatial mapping of therapeutic services: a systematic review |
| title_fullStr | Prevalence of babies born with neural tube defects and geospatial mapping of therapeutic services: a systematic review |
| title_full_unstemmed | Prevalence of babies born with neural tube defects and geospatial mapping of therapeutic services: a systematic review |
| title_short | Prevalence of babies born with neural tube defects and geospatial mapping of therapeutic services: a systematic review |
| title_sort | prevalence of babies born with neural tube defects and geospatial mapping of therapeutic services a systematic review |
| topic | Accessibility of Healthcare Geospatial Mapping Healthcare Disparities Neural Tube Defects Policy Reform |
| url | http://hdl.handle.net/11427/41932 |
| work_keys_str_mv | AT zoloossouandreyvan prevalenceofbabiesbornwithneuraltubedefectsandgeospatialmappingoftherapeuticservicesasystematicreview |