Full Text Available
Note: Clicking the button above will open the full text document at the original institutional repository in a new window.
MPhil in pulmonary haemorrhage in children in Cape Town
Introduction: Diffuse alveolar haemorrhage (DAH) is a rare condition in childhood which carries high morbidity and mortality. Outcomes are improved by initiating appropriate investigations to ensure early diagnosis and institute correct and timely management. Objectives: To understand the clinicopat...
Saved in:
| Main Author: | |
|---|---|
| Other Authors: | |
| Format: | Thesis |
| Language: | English English |
| Published: |
Department of Paediatrics and Child Health
2025
|
| Subjects: | |
| Tags: |
No Tags, Be the first to tag this record!
|
| _version_ | 1867613244595634176 |
|---|---|
| access_status_str | Open Access |
| author | Masu, Adelaide Ngina |
| author2 | Vanker, Aneesa |
| author_browse | Masu, Adelaide Ngina Vanker, Aneesa |
| author_facet | Vanker, Aneesa Masu, Adelaide Ngina |
| author_sort | Masu, Adelaide Ngina |
| collection | Thesis |
| description | Introduction: Diffuse alveolar haemorrhage (DAH) is a rare condition in childhood which carries high morbidity and mortality. Outcomes are improved by initiating appropriate investigations to ensure early diagnosis and institute correct and timely management. Objectives: To understand the clinicopathological features of DAH and its management on the outcomes of children with this diagnosis. Methods: A descriptive study was conducted on children attending a tertiary centre pulmonology clinic from the period 2000-2022. A review of the clinical data, investigations and lung biopsy results was done and outcomes were reported. Results: Sixteen children were included in the study. The median age at presentation was 1.79 years (IQR 0.48-3.15). At presentation, the median haemoglobulin (Hb)was 5.4 (IQR 3.6-85). Five out of16(31%) had haemoptysis. Seven children showed a pulmonary IgA vasculitis on biopsy. Of the most recent spirometry 5/14 (38.46) had a restrictive pattern. At diagnosis 6/16 (37%) received intravenous methyl-prednisone and 10/16(63%) received oral prednisone as treatment. The children who received more than one immunosuppressant agent as management were 14/16 (87%). Ten out of 16 children are in remission. Conclusion: Early diagnosis of DAH and multidrug management seems to improve outcomes. The finding of isolated IgA vasculitis on lung biopsy associated with DAH has not been well described. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/42065 |
| institution | University of Cape Town (South Africa) |
| language | English eng |
| last_indexed | 2026-06-10T12:33:04.194Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2025 |
| publishDateRange | 2025 |
| publishDateSort | 2025 |
| publisher | Department of Paediatrics and Child Health |
| publisherStr | Department of Paediatrics and Child Health |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/42065 MPhil in pulmonary haemorrhage in children in Cape Town Masu, Adelaide Ngina Vanker, Aneesa Gray, Diane Diffuse alveolar haemorrhage Cape Town Introduction: Diffuse alveolar haemorrhage (DAH) is a rare condition in childhood which carries high morbidity and mortality. Outcomes are improved by initiating appropriate investigations to ensure early diagnosis and institute correct and timely management. Objectives: To understand the clinicopathological features of DAH and its management on the outcomes of children with this diagnosis. Methods: A descriptive study was conducted on children attending a tertiary centre pulmonology clinic from the period 2000-2022. A review of the clinical data, investigations and lung biopsy results was done and outcomes were reported. Results: Sixteen children were included in the study. The median age at presentation was 1.79 years (IQR 0.48-3.15). At presentation, the median haemoglobulin (Hb)was 5.4 (IQR 3.6-85). Five out of16(31%) had haemoptysis. Seven children showed a pulmonary IgA vasculitis on biopsy. Of the most recent spirometry 5/14 (38.46) had a restrictive pattern. At diagnosis 6/16 (37%) received intravenous methyl-prednisone and 10/16(63%) received oral prednisone as treatment. The children who received more than one immunosuppressant agent as management were 14/16 (87%). Ten out of 16 children are in remission. Conclusion: Early diagnosis of DAH and multidrug management seems to improve outcomes. The finding of isolated IgA vasculitis on lung biopsy associated with DAH has not been well described. 2025-10-30T12:22:13Z 2025-10-30T12:22:13Z 2025 2025-10-30T12:17:54Z Thesis / Dissertation Masters Masters http://hdl.handle.net/11427/42065 en eng application/pdf Department of Paediatrics and Child Health Faculty of Health Sciences University of Cape Town |
| spellingShingle | Diffuse alveolar haemorrhage Cape Town Masu, Adelaide Ngina MPhil in pulmonary haemorrhage in children in Cape Town |
| thesis_degree_str | Master's |
| title | MPhil in pulmonary haemorrhage in children in Cape Town |
| title_full | MPhil in pulmonary haemorrhage in children in Cape Town |
| title_fullStr | MPhil in pulmonary haemorrhage in children in Cape Town |
| title_full_unstemmed | MPhil in pulmonary haemorrhage in children in Cape Town |
| title_short | MPhil in pulmonary haemorrhage in children in Cape Town |
| title_sort | mphil in pulmonary haemorrhage in children in cape town |
| topic | Diffuse alveolar haemorrhage Cape Town |
| url | http://hdl.handle.net/11427/42065 |
| work_keys_str_mv | AT masuadelaidengina mphilinpulmonaryhaemorrhageinchildrenincapetown |