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Evolutionary analysis and functional characterization of the forkhead transcription factor FoxG1
Includes bibliographical references (leaves 103-110).
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
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Department of Molecular and Cell Biology
2014
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| _version_ | 1867613260804521984 |
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| access_status_str | Open Access |
| author | Bredenkamp, Nicholas |
| author2 | Illing, Nicola |
| author_browse | Bredenkamp, Nicholas Illing, Nicola |
| author_facet | Illing, Nicola Bredenkamp, Nicholas |
| author_sort | Bredenkamp, Nicholas |
| collection | Thesis |
| description | Includes bibliographical references (leaves 103-110). |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/4243 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:33:19.547Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Department of Molecular and Cell Biology |
| publisherStr | Department of Molecular and Cell Biology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/4243 Evolutionary analysis and functional characterization of the forkhead transcription factor FoxG1 Bredenkamp, Nicholas Illing, Nicola Molecular Biology Includes bibliographical references (leaves 103-110). Forhead box G1 (FoxG1) is a winged-helix transcription factor that plays a crucial role in the development of the telecephalon, the most rostral region of the brain Here, FoxG1 acts as a transcriptional repressor and maintains the population of cortical progenitor cells by promoting their proliferation and inhibiting differrentiation. Vertebrate FoxG1 orthologs have highly conserved DNA-binding and corbosy-terminal domains that have functional roles. Conversely, no functional role has yet been assigned to the N-terminal domain which shows a high degree of variability across vertebrates, with a remarkable stretch of consecutive histidine, proline and glutamine (HPQ) residues in the mammalian orthologs. In this study it was tested whether differences in FoxG1 sequence amongst vertebrates might account for the increased cortex size of mammals compared to non-mammals. Furthermore, changes in the sub-cellular localization of FoxG1 in response to fibroblast growth factor 2 (FGF-2) were investigated in a neural precursor cell line. 2014-07-30T17:35:36Z 2014-07-30T17:35:36Z 2006 Master Thesis Masters MSc http://hdl.handle.net/11427/4243 eng application/pdf Department of Molecular and Cell Biology Faculty of Science University of Cape Town |
| spellingShingle | Molecular Biology Bredenkamp, Nicholas Evolutionary analysis and functional characterization of the forkhead transcription factor FoxG1 |
| thesis_degree_str | Master's |
| title | Evolutionary analysis and functional characterization of the forkhead transcription factor FoxG1 |
| title_full | Evolutionary analysis and functional characterization of the forkhead transcription factor FoxG1 |
| title_fullStr | Evolutionary analysis and functional characterization of the forkhead transcription factor FoxG1 |
| title_full_unstemmed | Evolutionary analysis and functional characterization of the forkhead transcription factor FoxG1 |
| title_short | Evolutionary analysis and functional characterization of the forkhead transcription factor FoxG1 |
| title_sort | evolutionary analysis and functional characterization of the forkhead transcription factor foxg1 |
| topic | Molecular Biology |
| url | http://hdl.handle.net/11427/4243 |
| work_keys_str_mv | AT bredenkampnicholas evolutionaryanalysisandfunctionalcharacterizationoftheforkheadtranscriptionfactorfoxg1 |