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The structure of testis angiotensin-converting enzyme (tACE-g13) in complex with the inhibitor RXPA380
Includes bibliographical references.
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Department of Molecular and Cell Biology
2014
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| _version_ | 1867613213919543296 |
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| access_status_str | Open Access |
| author | Chitapi, Itai |
| author2 | Sewell, Bryan Trevor |
| author_browse | Chitapi, Itai Sewell, Bryan Trevor |
| author_facet | Sewell, Bryan Trevor Chitapi, Itai |
| author_sort | Chitapi, Itai |
| collection | Thesis |
| description | Includes bibliographical references. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/4248 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:32:34.479Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Department of Molecular and Cell Biology |
| publisherStr | Department of Molecular and Cell Biology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/4248 The structure of testis angiotensin-converting enzyme (tACE-g13) in complex with the inhibitor RXPA380 Chitapi, Itai Sewell, Bryan Trevor Sturrock, E D Structural Biology Includes bibliographical references. Angiotensin-converting enzyme (ACE), a zinc metalloprotease, is a key regulator of the mammalian renin-angiotensin system (RAS) Primarily, ACF is a dipeptidl peptidase which cleaves angiotensin I to produce angiotensin II, a potent vasoconstrictor. By the same enzymatic mechanism, ACE also inactivates the vasodilator bradykinin. The main overall effect of these actions is an increase in blood pressure. Several ACF inhibitors have been developed as drugs for the treatment of myocardial infarction, hypertension, kidney failure and heart failure. 2014-07-30T17:36:13Z 2014-07-30T17:36:13Z 2006 Master Thesis Masters MSc http://hdl.handle.net/11427/4248 eng application/pdf Department of Molecular and Cell Biology Faculty of Science University of Cape Town |
| spellingShingle | Structural Biology Chitapi, Itai The structure of testis angiotensin-converting enzyme (tACE-g13) in complex with the inhibitor RXPA380 |
| thesis_degree_str | Master's |
| title | The structure of testis angiotensin-converting enzyme (tACE-g13) in complex with the inhibitor RXPA380 |
| title_full | The structure of testis angiotensin-converting enzyme (tACE-g13) in complex with the inhibitor RXPA380 |
| title_fullStr | The structure of testis angiotensin-converting enzyme (tACE-g13) in complex with the inhibitor RXPA380 |
| title_full_unstemmed | The structure of testis angiotensin-converting enzyme (tACE-g13) in complex with the inhibitor RXPA380 |
| title_short | The structure of testis angiotensin-converting enzyme (tACE-g13) in complex with the inhibitor RXPA380 |
| title_sort | structure of testis angiotensin converting enzyme tace g13 in complex with the inhibitor rxpa380 |
| topic | Structural Biology |
| url | http://hdl.handle.net/11427/4248 |
| work_keys_str_mv | AT chitapiitai thestructureoftestisangiotensinconvertingenzymetaceg13incomplexwiththeinhibitorrxpa380 AT chitapiitai structureoftestisangiotensinconvertingenzymetaceg13incomplexwiththeinhibitorrxpa380 |