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Medium term health and quality of life outcomes in a cohort of children with MIS-C in Cape Town, South Africa
Background: Multisystem inflammatory syndrome in children (MIS-C) is a disease that occurs after exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Its short term effects have been documented but little data exist on the longer term effects of MIS-C on the health and quality o...
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| Format: | Thesis |
| Language: | English English |
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Department of Paediatrics and Child Health
2026
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| _version_ | 1867613320957132800 |
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| access_status_str | Open Access |
| author | Phoya, Frank |
| author2 | Webb, Kate |
| author_browse | Phoya, Frank Webb, Kate |
| author_facet | Webb, Kate Phoya, Frank |
| author_sort | Phoya, Frank |
| collection | Thesis |
| description | Background: Multisystem inflammatory syndrome in children (MIS-C) is a disease that occurs after exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Its short term effects have been documented but little data exist on the longer term effects of MIS-C on the health and quality of life of patients. The objective of this study was to assess the long-term effects of MIS-C on the quality of life of children. Methods: This study was a prospective, case control, cohort study. We included 24 participants with previous MIS-C and 20 children with juvenile idiopathic arthritis (JIA) as a positive comparator group. All children were examined and completed a paediatric quality of life (PedsQL) generic inventory score. This score was used to evaluate the school functioning, social, emotional, and physical domains of the two groups. Results: All participants with previous MIS-C made a full recovery with normal physical examination after a median of 705 days after acute MIS-C. The PedsQL inventory revealed that 16.7% of the children with previous MIS-C showed a deficit in the physical domain compared to 60% of the children with JIA (p<0.001). There was a deficit in the psychosocial domain (which combines emotional, social and educational scores) in 12.5% children with previous MIS-C compared to 40% children with JIA (p=0.035) Conclusions: In 24 children with previous MIS-C, after approximately 2 years, no medical complications were reported. A small proportion felt a prolonged effect on their quality of life even after making a full recovery, which was less severe than in children with JIA. This highlights the need to continue to follow up these patients and offer more comprehensive long-term care. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/42646 |
| institution | University of Cape Town (South Africa) |
| language | English eng |
| last_indexed | 2026-06-10T12:34:14.045Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2026 |
| publishDateRange | 2026 |
| publishDateSort | 2026 |
| publisher | Department of Paediatrics and Child Health |
| publisherStr | Department of Paediatrics and Child Health |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/42646 Medium term health and quality of life outcomes in a cohort of children with MIS-C in Cape Town, South Africa Phoya, Frank Webb, Kate Scott, Christiaan Multisystem inflammatory syndrome Children Cape Town Background: Multisystem inflammatory syndrome in children (MIS-C) is a disease that occurs after exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Its short term effects have been documented but little data exist on the longer term effects of MIS-C on the health and quality of life of patients. The objective of this study was to assess the long-term effects of MIS-C on the quality of life of children. Methods: This study was a prospective, case control, cohort study. We included 24 participants with previous MIS-C and 20 children with juvenile idiopathic arthritis (JIA) as a positive comparator group. All children were examined and completed a paediatric quality of life (PedsQL) generic inventory score. This score was used to evaluate the school functioning, social, emotional, and physical domains of the two groups. Results: All participants with previous MIS-C made a full recovery with normal physical examination after a median of 705 days after acute MIS-C. The PedsQL inventory revealed that 16.7% of the children with previous MIS-C showed a deficit in the physical domain compared to 60% of the children with JIA (p<0.001). There was a deficit in the psychosocial domain (which combines emotional, social and educational scores) in 12.5% children with previous MIS-C compared to 40% children with JIA (p=0.035) Conclusions: In 24 children with previous MIS-C, after approximately 2 years, no medical complications were reported. A small proportion felt a prolonged effect on their quality of life even after making a full recovery, which was less severe than in children with JIA. This highlights the need to continue to follow up these patients and offer more comprehensive long-term care. 2026-01-22T07:17:14Z 2026-01-22T07:17:14Z 2025 2026-01-22T07:11:57Z Thesis / Dissertation Masters Masters http://hdl.handle.net/11427/42646 en eng application/pdf Department of Paediatrics and Child Health Faculty of Health Sciences University of Cape Town |
| spellingShingle | Multisystem inflammatory syndrome Children Cape Town Phoya, Frank Medium term health and quality of life outcomes in a cohort of children with MIS-C in Cape Town, South Africa |
| thesis_degree_str | Master's |
| title | Medium term health and quality of life outcomes in a cohort of children with MIS-C in Cape Town, South Africa |
| title_full | Medium term health and quality of life outcomes in a cohort of children with MIS-C in Cape Town, South Africa |
| title_fullStr | Medium term health and quality of life outcomes in a cohort of children with MIS-C in Cape Town, South Africa |
| title_full_unstemmed | Medium term health and quality of life outcomes in a cohort of children with MIS-C in Cape Town, South Africa |
| title_short | Medium term health and quality of life outcomes in a cohort of children with MIS-C in Cape Town, South Africa |
| title_sort | medium term health and quality of life outcomes in a cohort of children with mis c in cape town south africa |
| topic | Multisystem inflammatory syndrome Children Cape Town |
| url | http://hdl.handle.net/11427/42646 |
| work_keys_str_mv | AT phoyafrank mediumtermhealthandqualityoflifeoutcomesinacohortofchildrenwithmiscincapetownsouthafrica |