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How accurate is translaryngeal ultrasound when compared to flexible nasal endoscopy in viewing vocal cord mobility in children?

Objectives: Flexible fibreoptic laryngoscopy (FFL) is currently the gold standard for assessment of true vocal cord (TVC) mobility but is invasive and not without risk. The COVID-19 pandemic has led to growing interest in assessment tools that avoid aerosol generation and risk for transmission of di...

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Main Author: Ramyead, Divya Pallavi
Other Authors: Peer, Shazia
Format: Thesis
Language:English
English
Published: Division of General Surgery 2026
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access_status_str Open Access
author Ramyead, Divya Pallavi
author2 Peer, Shazia
author_browse Peer, Shazia
Ramyead, Divya Pallavi
author_facet Peer, Shazia
Ramyead, Divya Pallavi
author_sort Ramyead, Divya Pallavi
collection Thesis
description Objectives: Flexible fibreoptic laryngoscopy (FFL) is currently the gold standard for assessment of true vocal cord (TVC) mobility but is invasive and not without risk. The COVID-19 pandemic has led to growing interest in assessment tools that avoid aerosol generation and risk for transmission of disease. Transcutaneous laryngeal ultrasonography (TLUS) is a potentially useful, non-invasive alternative diagnostic tool for assessing true vocal cord (TVC) mobility.The aim was to determine the accuracy of an application-based TLUS as a screening tool for mobility of the true vocal cords (TVC), and to assess the feasibility of its use by an otolaryngologist not formally trained in ultrasonography. Methods: This was a prospective cohort study conducted after approval by human research ethics committee (HREC 202/2021). Forty children attending the ENT clinic at Red Cross War Memorial Children's Hospital (RCWMCH) for an upper airway assessment with FFL were recruited. Exclusion criteria were children on oxygen; with airway instability, and with behavioural disorders. The first author (DR), an ENT registrar without prior knowledge of ultrasonography, was trained by a consultant radiologist to use the Lumify® handheld ultrasound probe and application tool to assess the larynx and true vocal cord mobility. Combined TLUS and FFLs, short, looped and anonymised videos were formulated. Two qualified ENT specialists (neither trained in ultrasonography) consented to evaluate videos for true vocal cord mobility. Results: In total, 135 videos were obtained from 40 participants. Ages ranged from10 days to 9 years, and the genders were equally represented. On FFL, 92.5% (n=37/40) had normal TVC mobility and 7.5% (n=3/40) had unilateral TVC palsy. The overall accuracy of TLUS evaluation was 95.5% (sensitivity of 100%, specificity of 60%). Although the proportion of cases where normal mobility was correctly identified was 93.3% (n=120/135), the proportion of cases in which abnormal mobility (unilateral vocal cord mobility) was present and correctly identified was 100% (n=135/135). The reliability of TLUS when compared to FFL showed a p value <0.001 and a 100% agreement between ENT specialists evaluating the shared videos. Conclusions: Our study shows TLUS to be a reliable method of assessing TVC mobility. It is also portable, non–invasive and easy-to-use, making it a potentially useful screening tool especially in resource-limited settings, where FFL might not be readily available. Furthermore, it has potential benefit as a screening tool for TVC assessment for practitioners other than radiologists, e.g., otolaryngologists, who have a good understanding of laryngeal anatomy. More studies are needed to fully elucidate use of diagnostic and therapeutic ultrasound in children with airway conditions.
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provenance_str_mv Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository
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spelling oai:open.uct.ac.za:11427/42669 How accurate is translaryngeal ultrasound when compared to flexible nasal endoscopy in viewing vocal cord mobility in children? Ramyead, Divya Pallavi Peer, Shazia Translaryngeal ultrasound flexible fibre-optic laryngoscopy non-aerosol generating procedure non-invasive vocal cord mobility paediatric airway vocal cord paresis vocal cord palsy Objectives: Flexible fibreoptic laryngoscopy (FFL) is currently the gold standard for assessment of true vocal cord (TVC) mobility but is invasive and not without risk. The COVID-19 pandemic has led to growing interest in assessment tools that avoid aerosol generation and risk for transmission of disease. Transcutaneous laryngeal ultrasonography (TLUS) is a potentially useful, non-invasive alternative diagnostic tool for assessing true vocal cord (TVC) mobility.The aim was to determine the accuracy of an application-based TLUS as a screening tool for mobility of the true vocal cords (TVC), and to assess the feasibility of its use by an otolaryngologist not formally trained in ultrasonography. Methods: This was a prospective cohort study conducted after approval by human research ethics committee (HREC 202/2021). Forty children attending the ENT clinic at Red Cross War Memorial Children's Hospital (RCWMCH) for an upper airway assessment with FFL were recruited. Exclusion criteria were children on oxygen; with airway instability, and with behavioural disorders. The first author (DR), an ENT registrar without prior knowledge of ultrasonography, was trained by a consultant radiologist to use the Lumify® handheld ultrasound probe and application tool to assess the larynx and true vocal cord mobility. Combined TLUS and FFLs, short, looped and anonymised videos were formulated. Two qualified ENT specialists (neither trained in ultrasonography) consented to evaluate videos for true vocal cord mobility. Results: In total, 135 videos were obtained from 40 participants. Ages ranged from10 days to 9 years, and the genders were equally represented. On FFL, 92.5% (n=37/40) had normal TVC mobility and 7.5% (n=3/40) had unilateral TVC palsy. The overall accuracy of TLUS evaluation was 95.5% (sensitivity of 100%, specificity of 60%). Although the proportion of cases where normal mobility was correctly identified was 93.3% (n=120/135), the proportion of cases in which abnormal mobility (unilateral vocal cord mobility) was present and correctly identified was 100% (n=135/135). The reliability of TLUS when compared to FFL showed a p value <0.001 and a 100% agreement between ENT specialists evaluating the shared videos. Conclusions: Our study shows TLUS to be a reliable method of assessing TVC mobility. It is also portable, non–invasive and easy-to-use, making it a potentially useful screening tool especially in resource-limited settings, where FFL might not be readily available. Furthermore, it has potential benefit as a screening tool for TVC assessment for practitioners other than radiologists, e.g., otolaryngologists, who have a good understanding of laryngeal anatomy. More studies are needed to fully elucidate use of diagnostic and therapeutic ultrasound in children with airway conditions. 2026-01-23T11:05:19Z 2026-01-23T11:05:19Z 2025 2026-01-22T11:13:36Z Thesis / Dissertation Masters MMed http://hdl.handle.net/11427/42669 en eng application/pdf Division of General Surgery Faculty of Health Sciences University of Cape Town
spellingShingle Translaryngeal ultrasound
flexible fibre-optic laryngoscopy
non-aerosol generating procedure
non-invasive
vocal cord mobility
paediatric airway
vocal cord paresis
vocal cord palsy
Ramyead, Divya Pallavi
How accurate is translaryngeal ultrasound when compared to flexible nasal endoscopy in viewing vocal cord mobility in children?
thesis_degree_str Master's
title How accurate is translaryngeal ultrasound when compared to flexible nasal endoscopy in viewing vocal cord mobility in children?
title_full How accurate is translaryngeal ultrasound when compared to flexible nasal endoscopy in viewing vocal cord mobility in children?
title_fullStr How accurate is translaryngeal ultrasound when compared to flexible nasal endoscopy in viewing vocal cord mobility in children?
title_full_unstemmed How accurate is translaryngeal ultrasound when compared to flexible nasal endoscopy in viewing vocal cord mobility in children?
title_short How accurate is translaryngeal ultrasound when compared to flexible nasal endoscopy in viewing vocal cord mobility in children?
title_sort how accurate is translaryngeal ultrasound when compared to flexible nasal endoscopy in viewing vocal cord mobility in children
topic Translaryngeal ultrasound
flexible fibre-optic laryngoscopy
non-aerosol generating procedure
non-invasive
vocal cord mobility
paediatric airway
vocal cord paresis
vocal cord palsy
url http://hdl.handle.net/11427/42669
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