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Construction and characterization of chimaeric human immunodefiency virus type 1 subtype C Gag virus-like particles
Includes bibliographical references (leaves 114-128).
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Department of Molecular and Cell Biology
2014
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| _version_ | 1867613182718115840 |
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| access_status_str | Open Access |
| author | Halsey, Richard James |
| author2 | Tanzer, Fiona |
| author_browse | Halsey, Richard James Tanzer, Fiona |
| author_facet | Tanzer, Fiona Halsey, Richard James |
| author_sort | Halsey, Richard James |
| collection | Thesis |
| description | Includes bibliographical references (leaves 114-128). |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/4269 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:32:05.102Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Department of Molecular and Cell Biology |
| publisherStr | Department of Molecular and Cell Biology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/4269 Construction and characterization of chimaeric human immunodefiency virus type 1 subtype C Gag virus-like particles Halsey, Richard James Tanzer, Fiona Jaffray, Ann Rybicki, Ed Cell Biology Includes bibliographical references (leaves 114-128). In this study I explored the possibility of making HIV-1 subtype C Pr55gag-based chimaeric virus-like particles (VLPs) as a boost to the HIV-IC multigene DNA vaccine pTHr.grttnC, which encodes a modified Gag-RT-Tat-Nef fusion protein (GRTTN). Furthermore, an attempt was made to produce VLP analogues to the HIV-IA polyepitope DNA vaccine pTHr.HIVA. A range of in-frame fusions with the C-termini of myristylation-competent p6-truncated Gag and native Pr55gag were made to test how the length of polypeptide and its sequence might affect VLP formation and structure. 2014-07-30T17:38:22Z 2014-07-30T17:38:22Z 2006 Master Thesis Masters MSc http://hdl.handle.net/11427/4269 eng application/pdf Department of Molecular and Cell Biology Faculty of Science University of Cape Town |
| spellingShingle | Cell Biology Halsey, Richard James Construction and characterization of chimaeric human immunodefiency virus type 1 subtype C Gag virus-like particles |
| thesis_degree_str | Master's |
| title | Construction and characterization of chimaeric human immunodefiency virus type 1 subtype C Gag virus-like particles |
| title_full | Construction and characterization of chimaeric human immunodefiency virus type 1 subtype C Gag virus-like particles |
| title_fullStr | Construction and characterization of chimaeric human immunodefiency virus type 1 subtype C Gag virus-like particles |
| title_full_unstemmed | Construction and characterization of chimaeric human immunodefiency virus type 1 subtype C Gag virus-like particles |
| title_short | Construction and characterization of chimaeric human immunodefiency virus type 1 subtype C Gag virus-like particles |
| title_sort | construction and characterization of chimaeric human immunodefiency virus type 1 subtype c gag virus like particles |
| topic | Cell Biology |
| url | http://hdl.handle.net/11427/4269 |
| work_keys_str_mv | AT halseyrichardjames constructionandcharacterizationofchimaerichumanimmunodefiencyvirustype1subtypecgagviruslikeparticles |