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The international prognostic score and HIV status predict red cell concentrate transfusion needs in Hodgkin lymphoma

Despite the burden of anaemia among Hodgkin Lymphoma (HL) patients, data evaluating red cell concentrate transfusion is limited. We retrospectively studied 285 newly diagnosed HL patients who received first-line ABVD treatment at Groote Schuur Hospital, Cape Town. HIV prevalence in the cohort was 39...

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Main Author: Simba, Kudakwashe
Other Authors: Verburgh, Estelle
Format: Thesis
Language:English
English
Published: Department of Medicine 2026
Subjects:
HIV
Hodgkin lymphoma
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access_status_str Open Access
author Simba, Kudakwashe
author2 Verburgh, Estelle
author_browse Simba, Kudakwashe
Verburgh, Estelle
author_facet Verburgh, Estelle
Simba, Kudakwashe
author_sort Simba, Kudakwashe
collection Thesis
description Despite the burden of anaemia among Hodgkin Lymphoma (HL) patients, data evaluating red cell concentrate transfusion is limited. We retrospectively studied 285 newly diagnosed HL patients who received first-line ABVD treatment at Groote Schuur Hospital, Cape Town. HIV prevalence in the cohort was 39.5% and 74.2% of patients had advanced stage HL. Patient prognosis was scored using the HL International Prognostic Score (IPS-7) and HL IPS-3. Seventy (24.6%) patients were transfused with a median of 2(IQR 1-5) units per patient. Compared to HIV-negative patients, more HIV-positive patients were transfused (14.1% vs 40.4%, P<0.001) and received more units, median 2(IQR 1-3) vs. 3(IQR 2-5), P=0.035. HL IPS-7 (OR 2.1, P<0.001) and HL IPS-3 (OR 2.6, P<0.001) were independently associated with transfusion. HL IPS-7, HL IPS-3 and HIV positivity remained associated with transfusion after adjusting for covariates. For patients with newly diagnosed HL, HL IPS-7, HL IPS-3 and HIV status predicted transfusion.
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institution University of Cape Town (South Africa)
language English
eng
last_indexed 2026-06-10T12:40:08.059Z
license_str Not specified — see source repository
provenance_str_mv Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository
publishDate 2026
publishDateRange 2026
publishDateSort 2026
publisher Department of Medicine
publisherStr Department of Medicine
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source_str UCTD — University of Cape Town Open Access Repository
spelling oai:open.uct.ac.za:11427/42775 The international prognostic score and HIV status predict red cell concentrate transfusion needs in Hodgkin lymphoma Simba, Kudakwashe Verburgh, Estelle HIV Hodgkin lymphoma Despite the burden of anaemia among Hodgkin Lymphoma (HL) patients, data evaluating red cell concentrate transfusion is limited. We retrospectively studied 285 newly diagnosed HL patients who received first-line ABVD treatment at Groote Schuur Hospital, Cape Town. HIV prevalence in the cohort was 39.5% and 74.2% of patients had advanced stage HL. Patient prognosis was scored using the HL International Prognostic Score (IPS-7) and HL IPS-3. Seventy (24.6%) patients were transfused with a median of 2(IQR 1-5) units per patient. Compared to HIV-negative patients, more HIV-positive patients were transfused (14.1% vs 40.4%, P<0.001) and received more units, median 2(IQR 1-3) vs. 3(IQR 2-5), P=0.035. HL IPS-7 (OR 2.1, P<0.001) and HL IPS-3 (OR 2.6, P<0.001) were independently associated with transfusion. HL IPS-7, HL IPS-3 and HIV positivity remained associated with transfusion after adjusting for covariates. For patients with newly diagnosed HL, HL IPS-7, HL IPS-3 and HIV status predicted transfusion. 2026-01-30T09:09:02Z 2026-01-30T09:09:02Z 2025 2026-01-28T07:28:08Z Thesis / Dissertation Masters Masters http://hdl.handle.net/11427/42775 en eng application/pdf Department of Medicine Faculty of Health Sciences University of Cape Town
spellingShingle HIV
Hodgkin lymphoma
Simba, Kudakwashe
The international prognostic score and HIV status predict red cell concentrate transfusion needs in Hodgkin lymphoma
thesis_degree_str Master's
title The international prognostic score and HIV status predict red cell concentrate transfusion needs in Hodgkin lymphoma
title_full The international prognostic score and HIV status predict red cell concentrate transfusion needs in Hodgkin lymphoma
title_fullStr The international prognostic score and HIV status predict red cell concentrate transfusion needs in Hodgkin lymphoma
title_full_unstemmed The international prognostic score and HIV status predict red cell concentrate transfusion needs in Hodgkin lymphoma
title_short The international prognostic score and HIV status predict red cell concentrate transfusion needs in Hodgkin lymphoma
title_sort international prognostic score and hiv status predict red cell concentrate transfusion needs in hodgkin lymphoma
topic HIV
Hodgkin lymphoma
url http://hdl.handle.net/11427/42775
work_keys_str_mv AT simbakudakwashe theinternationalprognosticscoreandhivstatuspredictredcellconcentratetransfusionneedsinhodgkinlymphoma
AT simbakudakwashe internationalprognosticscoreandhivstatuspredictredcellconcentratetransfusionneedsinhodgkinlymphoma

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