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Structure and metabolism of bovine aortic proteoglycans
Although a number of studies of arterial glycosaminoglycans have been carried out, there is comparatively little information available regarding the native state in which these glycosaminoglycans occur, namely covalently bound to protein to form proteoglycans. There are numerous factors that make ar...
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| Format: | Thesis |
| Language: | English English |
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Division of Biomedical Engineering
2026
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| _version_ | 1867613344081379328 |
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| access_status_str | Open Access |
| author | Murray, Eileen |
| author2 | Scott-Burden, Timothy |
| author_browse | Murray, Eileen Scott-Burden, Timothy |
| author_facet | Scott-Burden, Timothy Murray, Eileen |
| author_sort | Murray, Eileen |
| collection | Thesis |
| description | Although a number of studies of arterial glycosaminoglycans have been carried out, there is comparatively little information available regarding the native state in which these glycosaminoglycans occur, namely covalently bound to protein to form proteoglycans. There are numerous factors that make arterial proteoglycans difficult to study, such as their relatively low concentration in the tissue a s compared to cartilaginous tissue, and their association with the fibrous elements of the matrix which make quantitative extraction difficult. In recent years reports of characterizations of arterial proteoglycans have appeared in the literature but they differ markedly in several respects. In order to minimize such variables, proteoglycans isolated from pure medial tissue of bovine aortas from different age groups have been studied. Isolation of these proteoglycans was carried out essentially as described for their counterparts from cartilage. Furthermore, proteoglycans have been isolated from a cultured clonal line of foetal bovine aortic medial smooth muscle cells and comparison s made between the two sources of material in terms of their proteoglycan monomer size and glycosaminoglycan composition. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/42831 |
| institution | University of Cape Town (South Africa) |
| language | English eng |
| last_indexed | 2026-06-10T12:34:39.078Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2026 |
| publishDateRange | 2026 |
| publishDateSort | 2026 |
| publisher | Division of Biomedical Engineering |
| publisherStr | Division of Biomedical Engineering |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/42831 Structure and metabolism of bovine aortic proteoglycans Murray, Eileen Scott-Burden, Timothy arterial glycosaminoglycans proteoglycans Although a number of studies of arterial glycosaminoglycans have been carried out, there is comparatively little information available regarding the native state in which these glycosaminoglycans occur, namely covalently bound to protein to form proteoglycans. There are numerous factors that make arterial proteoglycans difficult to study, such as their relatively low concentration in the tissue a s compared to cartilaginous tissue, and their association with the fibrous elements of the matrix which make quantitative extraction difficult. In recent years reports of characterizations of arterial proteoglycans have appeared in the literature but they differ markedly in several respects. In order to minimize such variables, proteoglycans isolated from pure medial tissue of bovine aortas from different age groups have been studied. Isolation of these proteoglycans was carried out essentially as described for their counterparts from cartilage. Furthermore, proteoglycans have been isolated from a cultured clonal line of foetal bovine aortic medial smooth muscle cells and comparison s made between the two sources of material in terms of their proteoglycan monomer size and glycosaminoglycan composition. 2026-02-11T12:08:50Z 2026-02-11T12:08:50Z 1983 2026-02-11T12:04:29Z Thesis / Dissertation Doctoral PhD http://hdl.handle.net/11427/42831 en eng application/pdf Division of Biomedical Engineering Faculty of Health Sciences University of Cape Town |
| spellingShingle | arterial glycosaminoglycans proteoglycans Murray, Eileen Structure and metabolism of bovine aortic proteoglycans |
| thesis_degree_str | Doctoral |
| title | Structure and metabolism of bovine aortic proteoglycans |
| title_full | Structure and metabolism of bovine aortic proteoglycans |
| title_fullStr | Structure and metabolism of bovine aortic proteoglycans |
| title_full_unstemmed | Structure and metabolism of bovine aortic proteoglycans |
| title_short | Structure and metabolism of bovine aortic proteoglycans |
| title_sort | structure and metabolism of bovine aortic proteoglycans |
| topic | arterial glycosaminoglycans proteoglycans |
| url | http://hdl.handle.net/11427/42831 |
| work_keys_str_mv | AT murrayeileen structureandmetabolismofbovineaorticproteoglycans |