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Vasoactive prostanoids in normal and hypertensive pregnancies
The role of vasoactive prostanoids in the pathogenesis of the hypertensive diseases in pregnancy is currently under debate. Studies have demonstrated a generalised deficiency of vasodilator prostanoids, particularly prostacyclin and a disturbance of the vasodilator to vasoconstrictor balance in pre-...
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| Format: | Thesis |
| Language: | English English |
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Department of Obstetrics and Gynaecology
2026
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| _version_ | 1867613332613103616 |
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| access_status_str | Open Access |
| author | Railton, Angela |
| author2 | Davey, D A |
| author_browse | Davey, D A Railton, Angela |
| author_facet | Davey, D A Railton, Angela |
| author_sort | Railton, Angela |
| collection | Thesis |
| description | The role of vasoactive prostanoids in the pathogenesis of the hypertensive diseases in pregnancy is currently under debate. Studies have demonstrated a generalised deficiency of vasodilator prostanoids, particularly prostacyclin and a disturbance of the vasodilator to vasoconstrictor balance in pre-eclampsia. The first part of this thesis reviews the literature with regard to the pathophysiology of gestational hypertension and the factors and mechanisms which may be responsible for the causation of the disease, with particular reference to the role of the prostanoids. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/42959 |
| institution | University of Cape Town (South Africa) |
| language | English eng |
| last_indexed | 2026-06-10T12:34:27.383Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2026 |
| publishDateRange | 2026 |
| publishDateSort | 2026 |
| publisher | Department of Obstetrics and Gynaecology |
| publisherStr | Department of Obstetrics and Gynaecology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/42959 Vasoactive prostanoids in normal and hypertensive pregnancies Railton, Angela Davey, D A Hypertension in pregnancy The role of vasoactive prostanoids in the pathogenesis of the hypertensive diseases in pregnancy is currently under debate. Studies have demonstrated a generalised deficiency of vasodilator prostanoids, particularly prostacyclin and a disturbance of the vasodilator to vasoconstrictor balance in pre-eclampsia. The first part of this thesis reviews the literature with regard to the pathophysiology of gestational hypertension and the factors and mechanisms which may be responsible for the causation of the disease, with particular reference to the role of the prostanoids. 2026-03-12T13:52:57Z 2026-03-12T13:52:57Z 1988 2024-07-19T13:22:28Z Thesis / Dissertation Doctoral PhD http://hdl.handle.net/11427/42959 en eng application/pdf Department of Obstetrics and Gynaecology Faculty of Health Sciences University of Cape Town |
| spellingShingle | Hypertension in pregnancy Railton, Angela Vasoactive prostanoids in normal and hypertensive pregnancies |
| thesis_degree_str | Doctoral |
| title | Vasoactive prostanoids in normal and hypertensive pregnancies |
| title_full | Vasoactive prostanoids in normal and hypertensive pregnancies |
| title_fullStr | Vasoactive prostanoids in normal and hypertensive pregnancies |
| title_full_unstemmed | Vasoactive prostanoids in normal and hypertensive pregnancies |
| title_short | Vasoactive prostanoids in normal and hypertensive pregnancies |
| title_sort | vasoactive prostanoids in normal and hypertensive pregnancies |
| topic | Hypertension in pregnancy |
| url | http://hdl.handle.net/11427/42959 |
| work_keys_str_mv | AT railtonangela vasoactiveprostanoidsinnormalandhypertensivepregnancies |