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Molecular characterization of ABC-type multidrug efflux systems in Bifidobacterium longum subsp. longumT JCM 1217
Includes abstract.
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
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Department of Molecular and Cell Biology
2014
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| _version_ | 1867613165743767552 |
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| access_status_str | Open Access |
| author | Moodley, Clinton |
| author2 | Reid, Sharon J |
| author_browse | Moodley, Clinton Reid, Sharon J |
| author_facet | Reid, Sharon J Moodley, Clinton |
| author_sort | Moodley, Clinton |
| collection | Thesis |
| description | Includes abstract. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/4298 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:31:48.735Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Department of Molecular and Cell Biology |
| publisherStr | Department of Molecular and Cell Biology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/4298 Molecular characterization of ABC-type multidrug efflux systems in Bifidobacterium longum subsp. longumT JCM 1217 Moodley, Clinton Reid, Sharon J Abratt, Valerie Rose Cell Biology Includes abstract. Includes bibliographical references. A healthy and stable gastrointestinal microbiota is a vital feature of the innate immune system. It affords the host numerous health benefits and acts as a barrier against opportunistic gut infections. Probiotic bacterial supplements are, therefore, widely used in industry to promote good health. There is, however, a need to understand not only the factors underlying the health promoting capabilities of these bacteria, but also the intrinsic antimicrobial resistance mechanisms which these bacteria are known to harbour. These antibiotic resistance traits confer a competitive advantage on these bacteria over other bacterial species where they reside in the gut. It also allows them to survive during antibiotic therapy and they are able to continue conferring health benefits on the host. To better understand the mechanisms these bacteria utilize in conferring antibiotic resistance, genes which confer multidrug resistance by the active hydrolysis of ATP were studied here. These genes belong to the ATP-binding cassette (ABC) family of efflux transporters. 2014-07-30T17:40:12Z 2014-07-30T17:40:12Z 2011 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/4298 eng application/pdf Department of Molecular and Cell Biology Faculty of Science University of Cape Town |
| spellingShingle | Cell Biology Moodley, Clinton Molecular characterization of ABC-type multidrug efflux systems in Bifidobacterium longum subsp. longumT JCM 1217 |
| thesis_degree_str | Doctoral |
| title | Molecular characterization of ABC-type multidrug efflux systems in Bifidobacterium longum subsp. longumT JCM 1217 |
| title_full | Molecular characterization of ABC-type multidrug efflux systems in Bifidobacterium longum subsp. longumT JCM 1217 |
| title_fullStr | Molecular characterization of ABC-type multidrug efflux systems in Bifidobacterium longum subsp. longumT JCM 1217 |
| title_full_unstemmed | Molecular characterization of ABC-type multidrug efflux systems in Bifidobacterium longum subsp. longumT JCM 1217 |
| title_short | Molecular characterization of ABC-type multidrug efflux systems in Bifidobacterium longum subsp. longumT JCM 1217 |
| title_sort | molecular characterization of abc type multidrug efflux systems in bifidobacterium longum subsp longumt jcm 1217 |
| topic | Cell Biology |
| url | http://hdl.handle.net/11427/4298 |
| work_keys_str_mv | AT moodleyclinton molecularcharacterizationofabctypemultidrugeffluxsystemsinbifidobacteriumlongumsubsplongumtjcm1217 |