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Genomic distribution of histone H1 in budding yeast (Saccharomyces cerevisiae) : yeast chromosome III
Includes bibliographical references.
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
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Department of Molecular and Cell Biology
2014
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| _version_ | 1867613341488250880 |
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| access_status_str | Open Access |
| author | Priya, Vattem Padma |
| author2 | Patterton, Hugh |
| author_browse | Patterton, Hugh Priya, Vattem Padma |
| author_facet | Patterton, Hugh Priya, Vattem Padma |
| author_sort | Priya, Vattem Padma |
| collection | Thesis |
| description | Includes bibliographical references. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/4324 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:34:36.552Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Department of Molecular and Cell Biology |
| publisherStr | Department of Molecular and Cell Biology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/4324 Genomic distribution of histone H1 in budding yeast (Saccharomyces cerevisiae) : yeast chromosome III Priya, Vattem Padma Patterton, Hugh Cell Biology Includes bibliographical references. The linker histone HI binds to the nucleosome and is essential for the organization of nucleosomes into the 30-nm filament of the chromatin. This compaction of DNA has a well-characterized effect on DNA function. In Saccharomyces cerevisiae, HHO 1 encodes a putative linker histone with very significant homology to histone HI. In vitro chromatin assembly experiments with recombinant Hho 1 p have shown that it is able to complex with the dinucleosomes in a similar manner to histone HI. It has also been reported that disruption of HHOl has little affect on RNA levels. A longstanding issue concerns the location of Hho 1 p in the chromatin and studies have shown using immunoprecipitation technique with anti-HA antibody, that Hho 1 p shows a preferential binding to rDNA sequences. In this project we have tried to confirm the above results in wild type cells, using immunopurifi ed anti rHho 1 p antibody. 2014-07-30T17:41:43Z 2014-07-30T17:41:43Z 2002 Master Thesis Masters MMed http://hdl.handle.net/11427/4324 eng application/pdf Department of Molecular and Cell Biology Faculty of Science University of Cape Town |
| spellingShingle | Cell Biology Priya, Vattem Padma Genomic distribution of histone H1 in budding yeast (Saccharomyces cerevisiae) : yeast chromosome III |
| thesis_degree_str | Master's |
| title | Genomic distribution of histone H1 in budding yeast (Saccharomyces cerevisiae) : yeast chromosome III |
| title_full | Genomic distribution of histone H1 in budding yeast (Saccharomyces cerevisiae) : yeast chromosome III |
| title_fullStr | Genomic distribution of histone H1 in budding yeast (Saccharomyces cerevisiae) : yeast chromosome III |
| title_full_unstemmed | Genomic distribution of histone H1 in budding yeast (Saccharomyces cerevisiae) : yeast chromosome III |
| title_short | Genomic distribution of histone H1 in budding yeast (Saccharomyces cerevisiae) : yeast chromosome III |
| title_sort | genomic distribution of histone h1 in budding yeast saccharomyces cerevisiae yeast chromosome iii |
| topic | Cell Biology |
| url | http://hdl.handle.net/11427/4324 |
| work_keys_str_mv | AT priyavattempadma genomicdistributionofhistoneh1inbuddingyeastsaccharomycescerevisiaeyeastchromosomeiii |