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An experimental approach to determine the binding mode of yeast linker histone, Hho1p
Bibliography: leaves 108-120.
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
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Department of Molecular and Cell Biology
2014
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| _version_ | 1867613205438660608 |
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| access_status_str | Open Access |
| author | Smith, Elizabeth M |
| author2 | Patterton, Hugh |
| author_browse | Patterton, Hugh Smith, Elizabeth M |
| author_facet | Patterton, Hugh Smith, Elizabeth M |
| author_sort | Smith, Elizabeth M |
| collection | Thesis |
| description | Bibliography: leaves 108-120. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/4333 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:32:26.116Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Department of Molecular and Cell Biology |
| publisherStr | Department of Molecular and Cell Biology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/4333 An experimental approach to determine the binding mode of yeast linker histone, Hho1p Smith, Elizabeth M Patterton, Hugh Cell Biology Bibliography: leaves 108-120. In this study, we have developed an assay to investigate of the binding mode of yeast linker histone Hholp to nucleosomes, using magnetic bead pull-down assays. To understand the structural and regulatory role of, Hholp, the linker histone in Saccharomyces cerevisiae, and that of higher eukaryotes (Thoma et al., 1979), it is essential to determine the manner in which these histones associate with chromatin. It was previously proposed that Hh01p may bind to two nucleosomes simultaneously, where globular domain one and globular domain two bind to the adjacent nucleosomes. 2014-07-30T17:41:56Z 2014-07-30T17:41:56Z 2003 Master Thesis Masters MSc http://hdl.handle.net/11427/4333 eng application/pdf Department of Molecular and Cell Biology Faculty of Science University of Cape Town |
| spellingShingle | Cell Biology Smith, Elizabeth M An experimental approach to determine the binding mode of yeast linker histone, Hho1p |
| thesis_degree_str | Master's |
| title | An experimental approach to determine the binding mode of yeast linker histone, Hho1p |
| title_full | An experimental approach to determine the binding mode of yeast linker histone, Hho1p |
| title_fullStr | An experimental approach to determine the binding mode of yeast linker histone, Hho1p |
| title_full_unstemmed | An experimental approach to determine the binding mode of yeast linker histone, Hho1p |
| title_short | An experimental approach to determine the binding mode of yeast linker histone, Hho1p |
| title_sort | experimental approach to determine the binding mode of yeast linker histone hho1p |
| topic | Cell Biology |
| url | http://hdl.handle.net/11427/4333 |
| work_keys_str_mv | AT smithelizabethm anexperimentalapproachtodeterminethebindingmodeofyeastlinkerhistonehho1p AT smithelizabethm experimentalapproachtodeterminethebindingmodeofyeastlinkerhistonehho1p |