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Accuracy of intraoperative assessment of sentinel lymph nodes in breast cancer patients
Breast cancer remains a leading cause of cancer-related morbidity and mortality globally. Accurate staging is essential for appropriate management, yet breast cancer staging practices vary and are not universally standardized. Intraoperative sentinel lymph node biopsy (SLNB) with frozen section (FS)...
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| Format: | Thesis |
| Language: | English English |
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Department of Pathology
2026
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| _version_ | 1869483653538512896 |
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| access_status_str | Open Access |
| author | Fakier, Ghaalied |
| author2 | Chetty, Dharshnee Rama |
| author_browse | Chetty, Dharshnee Rama Fakier, Ghaalied |
| author_facet | Chetty, Dharshnee Rama Fakier, Ghaalied |
| author_sort | Fakier, Ghaalied |
| collection | Thesis |
| description | Breast cancer remains a leading cause of cancer-related morbidity and mortality globally. Accurate staging is essential for appropriate management, yet breast cancer staging practices vary and are not universally standardized. Intraoperative sentinel lymph node biopsy (SLNB) with frozen section (FS) analysis is commonly employed to detect axillary lymph node metastases. When nodal metastases are identified, axillary lymph node dissection (ALND) is often performed. However, ALND is associated with significant morbidity and can negatively impact quality of life. The increasing use of neoadjuvant chemotherapy (NAC) and radiotherapy has the potential to downstage disease, but intraoperative FS analysis remains relevant, identifying individuals needing ALND. While international data supports this trend, variability in healthcare systems and patient populations limits the generalizability of these findings to the South African context. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/43347 |
| institution | University of Cape Town (South Africa) |
| language | English eng |
| last_indexed | 2026-07-01T04:02:25.315Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2026 |
| publishDateRange | 2026 |
| publishDateSort | 2026 |
| publisher | Department of Pathology |
| publisherStr | Department of Pathology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/43347 Accuracy of intraoperative assessment of sentinel lymph nodes in breast cancer patients Fakier, Ghaalied Chetty, Dharshnee Rama Malherbe Francois Breast carcinoma, frozen section, sentinel lymph node, ACOSOG Z011, axillary Breast cancer remains a leading cause of cancer-related morbidity and mortality globally. Accurate staging is essential for appropriate management, yet breast cancer staging practices vary and are not universally standardized. Intraoperative sentinel lymph node biopsy (SLNB) with frozen section (FS) analysis is commonly employed to detect axillary lymph node metastases. When nodal metastases are identified, axillary lymph node dissection (ALND) is often performed. However, ALND is associated with significant morbidity and can negatively impact quality of life. The increasing use of neoadjuvant chemotherapy (NAC) and radiotherapy has the potential to downstage disease, but intraoperative FS analysis remains relevant, identifying individuals needing ALND. While international data supports this trend, variability in healthcare systems and patient populations limits the generalizability of these findings to the South African context. 2026-06-22T12:22:11Z 2026-06-22T12:22:11Z 2026 2026-06-22T11:26:57Z Thesis / Dissertation Masters MMed http://hdl.handle.net/11427/43347 en eng application/pdf Department of Pathology Faculty of Health Sciences University of Cape Town |
| spellingShingle | Breast carcinoma, frozen section, sentinel lymph node, ACOSOG Z011, axillary Fakier, Ghaalied Accuracy of intraoperative assessment of sentinel lymph nodes in breast cancer patients |
| thesis_degree_str | Master's |
| title | Accuracy of intraoperative assessment of sentinel lymph nodes in breast cancer patients |
| title_full | Accuracy of intraoperative assessment of sentinel lymph nodes in breast cancer patients |
| title_fullStr | Accuracy of intraoperative assessment of sentinel lymph nodes in breast cancer patients |
| title_full_unstemmed | Accuracy of intraoperative assessment of sentinel lymph nodes in breast cancer patients |
| title_short | Accuracy of intraoperative assessment of sentinel lymph nodes in breast cancer patients |
| title_sort | accuracy of intraoperative assessment of sentinel lymph nodes in breast cancer patients |
| topic | Breast carcinoma, frozen section, sentinel lymph node, ACOSOG Z011, axillary |
| url | http://hdl.handle.net/11427/43347 |
| work_keys_str_mv | AT fakierghaalied accuracyofintraoperativeassessmentofsentinellymphnodesinbreastcancerpatients |