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Investigating the relationship between plasma and intracellular concentrations of bedaquiline and its metabolite N-desmethyl bedaquiline (M2) in drug resistant-TB patients with and without HIV infection in South Africa
Both bedaquiline (approved by the FDA for use in pulmonary MDR-TB) and its metabolite, M2, exhibit intracellular antimycobacterial activity against tuberculosis. Understanding their intracellular pharmacokinetics is useful in elucidating the drug exposure-efficacy and exposure-toxicity relationships...
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| Format: | Thesis |
| Language: | English English |
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Department of Medicine
2026
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