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The genetics of lithium-induced adverse drug reactions in bipolar disorder patients : a pilot study
Includes abstract.
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Division of Human Genetics
2014
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| _version_ | 1867611317792145408 |
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| access_status_str | Open Access |
| author | Weideman, Reinette |
| author2 | Ramesar, Raj |
| author_browse | Ramesar, Raj Weideman, Reinette |
| author_facet | Ramesar, Raj Weideman, Reinette |
| author_sort | Weideman, Reinette |
| collection | Thesis |
| description | Includes abstract. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/6091 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Division of Human Genetics |
| publisherStr | Division of Human Genetics |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/6091 The genetics of lithium-induced adverse drug reactions in bipolar disorder patients : a pilot study Weideman, Reinette Ramesar, Raj Horn, Neil Medicine Includes abstract. Includes bibliographical references. Name of degree provided by the Faculty of Health Sciences. Lithium is regarded as the first-line pharmacotherapy for the treatment of acute mood episodes, suicide prevention and prophylactic treatment in patients with bipolar disorder (BPD). Response to lithium has a strong genetic component and lithium-responders have an increased frequency of BPD among their family members. Lithium has a narrow therapeutic index and 75-90% of patients on long-term lithium treatment experience one or more side effects, such as weight gain, cognitive decline and skin problems, amongst at least 20 side effects. The research project is immersed in a larger project on the genetics of bipolar disorder, in which a large number of individuals in families have been investigated over several years. The present pilot study explored whether single nucleotide polymorphisms (SNPs) within GSK3B, AKT1, ARRB2, GRIA2 and PPPARGC1A could be associated with the incidence and severity of lithium-induced side effects. 2014-08-13T13:51:51Z 2014-08-13T13:51:51Z 2013 Master Thesis Masters MSc http://hdl.handle.net/11427/6091 eng application/pdf Division of Human Genetics Faculty of Health Sciences University of Cape Town |
| spellingShingle | Medicine Weideman, Reinette The genetics of lithium-induced adverse drug reactions in bipolar disorder patients : a pilot study |
| thesis_degree_str | Master's |
| title | The genetics of lithium-induced adverse drug reactions in bipolar disorder patients : a pilot study |
| title_full | The genetics of lithium-induced adverse drug reactions in bipolar disorder patients : a pilot study |
| title_fullStr | The genetics of lithium-induced adverse drug reactions in bipolar disorder patients : a pilot study |
| title_full_unstemmed | The genetics of lithium-induced adverse drug reactions in bipolar disorder patients : a pilot study |
| title_short | The genetics of lithium-induced adverse drug reactions in bipolar disorder patients : a pilot study |
| title_sort | genetics of lithium induced adverse drug reactions in bipolar disorder patients a pilot study |
| topic | Medicine |
| url | http://hdl.handle.net/11427/6091 |
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