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Synthesis, antimalarial evaluation and structure-activity relationship in a series of dibenzlmethylamine (Dibemethin) derivatives of 4-amino-7-chloroquinoline
Includes abstract.
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
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Department of Chemistry
2014
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| _version_ | 1867613302165602304 |
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| access_status_str | Open Access |
| author | Zishiri, Vincent Kudakwashe |
| author2 | Egan, Timothy J |
| author_browse | Egan, Timothy J Zishiri, Vincent Kudakwashe |
| author_facet | Egan, Timothy J Zishiri, Vincent Kudakwashe |
| author_sort | Zishiri, Vincent Kudakwashe |
| collection | Thesis |
| description | Includes abstract. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/6280 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:33:59.204Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Department of Chemistry |
| publisherStr | Department of Chemistry |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/6280 Synthesis, antimalarial evaluation and structure-activity relationship in a series of dibenzlmethylamine (Dibemethin) derivatives of 4-amino-7-chloroquinoline Zishiri, Vincent Kudakwashe Egan, Timothy J Hunter, Roger Chemistry Includes abstract. Includes bibliographical references (leaves 138-154). A series of twelve 4-amino-7-chloroquinolines containing (N, N-dibenzylmethylamine) dibemethin side chains attached to the amino group of the quinoline were synthesized by reaction of aminomethyl dibemethins with 4,7-dichloroquinoline to give “dibemethinoquines”. The attachment between the quinoline ring and the side chain was varied from ortho, to meta to para. The aminomethyl dibemethin side chains were synthesized using the Staudinger reduction of azides or the reductive amination via oxime of an aldehyde. Derivatives in which the para substituent on the terminal phenyl ring were altered from the parent compound (X = H) by replacement with Cl, OCH₃ orNMe₂ group were also synthesized. The choice of substituents was based on the Topliss scheme. 2014-08-13T14:25:24Z 2014-08-13T14:25:24Z 2008 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/6280 eng application/pdf Department of Chemistry Faculty of Science University of Cape Town |
| spellingShingle | Chemistry Zishiri, Vincent Kudakwashe Synthesis, antimalarial evaluation and structure-activity relationship in a series of dibenzlmethylamine (Dibemethin) derivatives of 4-amino-7-chloroquinoline |
| thesis_degree_str | Doctoral |
| title | Synthesis, antimalarial evaluation and structure-activity relationship in a series of dibenzlmethylamine (Dibemethin) derivatives of 4-amino-7-chloroquinoline |
| title_full | Synthesis, antimalarial evaluation and structure-activity relationship in a series of dibenzlmethylamine (Dibemethin) derivatives of 4-amino-7-chloroquinoline |
| title_fullStr | Synthesis, antimalarial evaluation and structure-activity relationship in a series of dibenzlmethylamine (Dibemethin) derivatives of 4-amino-7-chloroquinoline |
| title_full_unstemmed | Synthesis, antimalarial evaluation and structure-activity relationship in a series of dibenzlmethylamine (Dibemethin) derivatives of 4-amino-7-chloroquinoline |
| title_short | Synthesis, antimalarial evaluation and structure-activity relationship in a series of dibenzlmethylamine (Dibemethin) derivatives of 4-amino-7-chloroquinoline |
| title_sort | synthesis antimalarial evaluation and structure activity relationship in a series of dibenzlmethylamine dibemethin derivatives of 4 amino 7 chloroquinoline |
| topic | Chemistry |
| url | http://hdl.handle.net/11427/6280 |
| work_keys_str_mv | AT zishirivincentkudakwashe synthesisantimalarialevaluationandstructureactivityrelationshipinaseriesofdibenzlmethylaminedibemethinderivativesof4amino7chloroquinoline |