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Bioactive chloroquine-based ligands and their gold complexes as potential novel antimalarial agents
Includes bibliographical references.
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Department of Chemistry
2014
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| _version_ | 1867613212501868544 |
|---|---|
| access_status_str | Open Access |
| author | Watermeyer, Nicholas D |
| author2 | Chibale, Kelly |
| author_browse | Chibale, Kelly Watermeyer, Nicholas D |
| author_facet | Chibale, Kelly Watermeyer, Nicholas D |
| author_sort | Watermeyer, Nicholas D |
| collection | Thesis |
| description | Includes bibliographical references. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/6283 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:32:33.381Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Department of Chemistry |
| publisherStr | Department of Chemistry |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/6283 Bioactive chloroquine-based ligands and their gold complexes as potential novel antimalarial agents Watermeyer, Nicholas D Chibale, Kelly Chemistry Includes bibliographical references. Includes bibliographical references. Chloroquine(CO)-derived 4-aminoquinolines have proven to be the most efficacious antimalarial drugs for both the treatment and prophylaxis of malaria. However, with the advent of drug resistance, their ability to treat the disease has been significantly hindered. Future research into the synthesis of new 4-aminoquinoline derivatives is warranted, since it has been found that the resistance is based on the identity of the side chain and not on the aminoquinoline ring, the functionality by which these compounds derive their activity. Consequently, the synthesis of CO derivatives with a modified side chain attached to a substituted quinoline ring is a reasonable approach in the search of novel antimalarial compounds that are active against drug-resistant parasite strains. 2014-08-13T14:25:31Z 2014-08-13T14:25:31Z 2008 Master Thesis Masters MSc http://hdl.handle.net/11427/6283 eng application/pdf Department of Chemistry Faculty of Science University of Cape Town |
| spellingShingle | Chemistry Watermeyer, Nicholas D Bioactive chloroquine-based ligands and their gold complexes as potential novel antimalarial agents |
| thesis_degree_str | Master's |
| title | Bioactive chloroquine-based ligands and their gold complexes as potential novel antimalarial agents |
| title_full | Bioactive chloroquine-based ligands and their gold complexes as potential novel antimalarial agents |
| title_fullStr | Bioactive chloroquine-based ligands and their gold complexes as potential novel antimalarial agents |
| title_full_unstemmed | Bioactive chloroquine-based ligands and their gold complexes as potential novel antimalarial agents |
| title_short | Bioactive chloroquine-based ligands and their gold complexes as potential novel antimalarial agents |
| title_sort | bioactive chloroquine based ligands and their gold complexes as potential novel antimalarial agents |
| topic | Chemistry |
| url | http://hdl.handle.net/11427/6283 |
| work_keys_str_mv | AT watermeyernicholasd bioactivechloroquinebasedligandsandtheirgoldcomplexesaspotentialnovelantimalarialagents |