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Structural and thermal characterisation of NSAIDs and cyclodextrin-NSAID complexes
Includes bibliographical references.
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Department of Chemistry
2014
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| _version_ | 1867613233751261184 |
|---|---|
| access_status_str | Open Access |
| author | Dean, Pamela Mary |
| author2 | Caira, Mino R |
| author_browse | Caira, Mino R Dean, Pamela Mary |
| author_facet | Caira, Mino R Dean, Pamela Mary |
| author_sort | Dean, Pamela Mary |
| collection | Thesis |
| description | Includes bibliographical references. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/6303 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:32:52.713Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Department of Chemistry |
| publisherStr | Department of Chemistry |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/6303 Structural and thermal characterisation of NSAIDs and cyclodextrin-NSAID complexes Dean, Pamela Mary Caira, Mino R Chemistry Includes bibliographical references. Non-steroidal anti-inflammatory drugs (NSAIDs) are used for the prevention of pain and inflammation. These symptoms are brought about by the action of biochemicals such as prostoglandins, which result from the conversion of a fatty acid, known as arachidonic acid, by the enzyme cyclooxygenase (COX) in the presence of oxygen. NSAIDs act on this biochemical pathway by inhibiting the COX enzyme, thereby exerting their analgesic effect. Since, however, the solubility and bioavailability of NSAIDs are generally poor, encapsulation of these drugs in cyclodextrins was attempted in order to alter their dissolution properties. 2014-08-13T14:26:10Z 2014-08-13T14:26:10Z 2004 Master Thesis Masters MSc http://hdl.handle.net/11427/6303 eng application/pdf Department of Chemistry Faculty of Science University of Cape Town |
| spellingShingle | Chemistry Dean, Pamela Mary Structural and thermal characterisation of NSAIDs and cyclodextrin-NSAID complexes |
| thesis_degree_str | Master's |
| title | Structural and thermal characterisation of NSAIDs and cyclodextrin-NSAID complexes |
| title_full | Structural and thermal characterisation of NSAIDs and cyclodextrin-NSAID complexes |
| title_fullStr | Structural and thermal characterisation of NSAIDs and cyclodextrin-NSAID complexes |
| title_full_unstemmed | Structural and thermal characterisation of NSAIDs and cyclodextrin-NSAID complexes |
| title_short | Structural and thermal characterisation of NSAIDs and cyclodextrin-NSAID complexes |
| title_sort | structural and thermal characterisation of nsaids and cyclodextrin nsaid complexes |
| topic | Chemistry |
| url | http://hdl.handle.net/11427/6303 |
| work_keys_str_mv | AT deanpamelamary structuralandthermalcharacterisationofnsaidsandcyclodextrinnsaidcomplexes |