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Antiprotozoal quinolines containing electrophilic moieties
Includes bibliographical references.
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
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Department of Chemistry
2014
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| _version_ | 1867613274128777217 |
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| access_status_str | Open Access |
| author | Ganto, Mlungiseleli Macdonald |
| author2 | Chibale, Kelly |
| author_browse | Chibale, Kelly Ganto, Mlungiseleli Macdonald |
| author_facet | Chibale, Kelly Ganto, Mlungiseleli Macdonald |
| author_sort | Ganto, Mlungiseleli Macdonald |
| collection | Thesis |
| description | Includes bibliographical references. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/6307 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:33:31.121Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Department of Chemistry |
| publisherStr | Department of Chemistry |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/6307 Antiprotozoal quinolines containing electrophilic moieties Ganto, Mlungiseleli Macdonald Chibale, Kelly Chemistry Includes bibliographical references. Compounds containing the quinoline moiety have been the mainstay of antimalarial chemotherapy. However, the emergence of resistant strains of Plasmodium falciparum, the causative agent of malaria, has compromised the efficacy of these antimalarial quinolines. Therefore the development of new efficient drugs is of critical importance. Extensive research has identified the cysteine proteases in malaria and other parasitic diseases as potential targets for new chemotherapy due to their critical roles in the life cycles of the causative agents. Due to their role in the antimalarial activity of clinically available drugs, quinolines were used as scaffolds to which electrophilic groups, such as thiosemicarbazone, a,β-unsaturated ketone and pyrazoline moieties were appended. 2014-08-13T14:26:17Z 2014-08-13T14:26:17Z 2004 Master Thesis Masters MSc http://hdl.handle.net/11427/6307 eng application/pdf Department of Chemistry Faculty of Science University of Cape Town |
| spellingShingle | Chemistry Ganto, Mlungiseleli Macdonald Antiprotozoal quinolines containing electrophilic moieties |
| thesis_degree_str | Master's |
| title | Antiprotozoal quinolines containing electrophilic moieties |
| title_full | Antiprotozoal quinolines containing electrophilic moieties |
| title_fullStr | Antiprotozoal quinolines containing electrophilic moieties |
| title_full_unstemmed | Antiprotozoal quinolines containing electrophilic moieties |
| title_short | Antiprotozoal quinolines containing electrophilic moieties |
| title_sort | antiprotozoal quinolines containing electrophilic moieties |
| topic | Chemistry |
| url | http://hdl.handle.net/11427/6307 |
| work_keys_str_mv | AT gantomlungiselelimacdonald antiprotozoalquinolinescontainingelectrophilicmoieties |