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Haematin-Quinoline interactions and structure-activity relationships in the antimalarial chloroquine and related compounds
Includes bibliographical references.
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Department of Chemistry
2014
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| _version_ | 1867614338946170880 |
|---|---|
| access_status_str | Open Access |
| author | Kaschula, Catherine Hart |
| author2 | Egan, Timothy J |
| author_browse | Egan, Timothy J Kaschula, Catherine Hart |
| author_facet | Egan, Timothy J Kaschula, Catherine Hart |
| author_sort | Kaschula, Catherine Hart |
| collection | Thesis |
| description | Includes bibliographical references. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/6316 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:50:28.005Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Department of Chemistry |
| publisherStr | Department of Chemistry |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/6316 Haematin-Quinoline interactions and structure-activity relationships in the antimalarial chloroquine and related compounds Kaschula, Catherine Hart Egan, Timothy J Hunter, Roger Chemistry Includes bibliographical references. The nature of the ferriprotoporphyrin IX (Fe(III)PPIX) antimalarial drug target and its interactions with aminoquinolines was investigated spectrophotometrically. The antiquity of malaria, which is caused by protozoan parasites of the genus Plasmodium, is demonstrated by the host specificity of over 100 parasite species found in reptiles, birds and mammals. The four species of plasmodia that infect man are P. vivax, P. malariae, P. ovale and P. falciparum; of which P. falciparum is the most deadly (Bruce-Chwatt 1981 ). 2014-08-13T14:26:37Z 2014-08-13T14:26:37Z 2002 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/6316 eng application/pdf Department of Chemistry Faculty of Science University of Cape Town |
| spellingShingle | Chemistry Kaschula, Catherine Hart Haematin-Quinoline interactions and structure-activity relationships in the antimalarial chloroquine and related compounds |
| thesis_degree_str | Doctoral |
| title | Haematin-Quinoline interactions and structure-activity relationships in the antimalarial chloroquine and related compounds |
| title_full | Haematin-Quinoline interactions and structure-activity relationships in the antimalarial chloroquine and related compounds |
| title_fullStr | Haematin-Quinoline interactions and structure-activity relationships in the antimalarial chloroquine and related compounds |
| title_full_unstemmed | Haematin-Quinoline interactions and structure-activity relationships in the antimalarial chloroquine and related compounds |
| title_short | Haematin-Quinoline interactions and structure-activity relationships in the antimalarial chloroquine and related compounds |
| title_sort | haematin quinoline interactions and structure activity relationships in the antimalarial chloroquine and related compounds |
| topic | Chemistry |
| url | http://hdl.handle.net/11427/6316 |
| work_keys_str_mv | AT kaschulacatherinehart haematinquinolineinteractionsandstructureactivityrelationshipsintheantimalarialchloroquineandrelatedcompounds |