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Development of new methodologies for functionalizing glycals and 1,2-cyclopropanated sugars, and applications in the synthesis of inhibitors of enzymes in the Mycobacteria
Includes bibliographical references (p. 177-186).
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Department of Chemistry
2014
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| _version_ | 1867614401083736064 |
|---|---|
| access_status_str | Open Access |
| author | Kinfe, Henok Hadgu |
| author2 | Gammon, David W |
| author_browse | Gammon, David W Kinfe, Henok Hadgu |
| author_facet | Gammon, David W Kinfe, Henok Hadgu |
| author_sort | Kinfe, Henok Hadgu |
| collection | Thesis |
| description | Includes bibliographical references (p. 177-186). |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/6318 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:51:27.263Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Department of Chemistry |
| publisherStr | Department of Chemistry |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/6318 Development of new methodologies for functionalizing glycals and 1,2-cyclopropanated sugars, and applications in the synthesis of inhibitors of enzymes in the Mycobacteria Kinfe, Henok Hadgu Gammon, David W Chemistry Includes bibliographical references (p. 177-186). Tuberculosis (TB) is a contagious respiratory disease caused by Mycobacterium tuberculosis. Due to lack of an efficient and short-term treatment of TB, the bacterium has become resistant to the first line antibiotics and the disease has ranked next to HIV/AIDS. A low molecular weight thiol called myctothiol protects the bacteria from many foreign stress factors and secures its survival. Studies have shown the mycothiol-deficient bacteria are hypersensitive to external stresses and hence inhibition of the biosynthesis of mycothiol could be a drug lead against TB. 2014-08-13T14:26:41Z 2014-08-13T14:26:41Z 2006 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/6318 eng application/pdf Department of Chemistry Faculty of Science University of Cape Town |
| spellingShingle | Chemistry Kinfe, Henok Hadgu Development of new methodologies for functionalizing glycals and 1,2-cyclopropanated sugars, and applications in the synthesis of inhibitors of enzymes in the Mycobacteria |
| thesis_degree_str | Doctoral |
| title | Development of new methodologies for functionalizing glycals and 1,2-cyclopropanated sugars, and applications in the synthesis of inhibitors of enzymes in the Mycobacteria |
| title_full | Development of new methodologies for functionalizing glycals and 1,2-cyclopropanated sugars, and applications in the synthesis of inhibitors of enzymes in the Mycobacteria |
| title_fullStr | Development of new methodologies for functionalizing glycals and 1,2-cyclopropanated sugars, and applications in the synthesis of inhibitors of enzymes in the Mycobacteria |
| title_full_unstemmed | Development of new methodologies for functionalizing glycals and 1,2-cyclopropanated sugars, and applications in the synthesis of inhibitors of enzymes in the Mycobacteria |
| title_short | Development of new methodologies for functionalizing glycals and 1,2-cyclopropanated sugars, and applications in the synthesis of inhibitors of enzymes in the Mycobacteria |
| title_sort | development of new methodologies for functionalizing glycals and 1 2 cyclopropanated sugars and applications in the synthesis of inhibitors of enzymes in the mycobacteria |
| topic | Chemistry |
| url | http://hdl.handle.net/11427/6318 |
| work_keys_str_mv | AT kinfehenokhadgu developmentofnewmethodologiesforfunctionalizingglycalsand12cyclopropanatedsugarsandapplicationsinthesynthesisofinhibitorsofenzymesinthemycobacteria |