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Utilisation of efficient reactions to combine moeities exhibiting biological activity to produce novel anti-infectives against HIV and malaria
Includes abstract.
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Department of Chemistry
2014
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| _version_ | 1867613195791761408 |
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| access_status_str | Open Access |
| author | Krein, Ze-ev |
| author2 | Chibale, Kelly |
| author_browse | Chibale, Kelly Krein, Ze-ev |
| author_facet | Chibale, Kelly Krein, Ze-ev |
| author_sort | Krein, Ze-ev |
| collection | Thesis |
| description | Includes abstract. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/6320 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:32:17.361Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Department of Chemistry |
| publisherStr | Department of Chemistry |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/6320 Utilisation of efficient reactions to combine moeities exhibiting biological activity to produce novel anti-infectives against HIV and malaria Krein, Ze-ev Chibale, Kelly Chemistry Includes abstract. Includes bibliographical references (leaves 151-155). Chloroquine (CQ) was previously identified as a potential anti-HIV agent and reported to inhibit the production of infectious viral particles at concentrations which are non toxic to human cultured cells. It is speculated that this activity is associated with the decreased production of the heavily glycosylated epitope 2G 12 which is found on the gp120 glycoprotein surface. The hypothesized mechanism involves CQ acting on a range of cellular targets. This work identifies CQ as a lead compound for the discovery of potentially inexpensive drugs and its ability to target cellular enzymes as opposed to viral enzymes may endow the compound with the capacity to oppose resistance. This previous work was the basis of this project and prompted a further investigation into whether the quinoline scaffold is the principal cause of CQ's activity and whether other rationally designed compounds which contain this scaffold would be able to maintain similar or even greater anti-HIV activity. In an attempt to achieve greater activity, the dual drug approach was utilized. 2014-08-13T14:26:43Z 2014-08-13T14:26:43Z 2007 Master Thesis Masters MSc http://hdl.handle.net/11427/6320 eng application/pdf Department of Chemistry Faculty of Science University of Cape Town |
| spellingShingle | Chemistry Krein, Ze-ev Utilisation of efficient reactions to combine moeities exhibiting biological activity to produce novel anti-infectives against HIV and malaria |
| thesis_degree_str | Master's |
| title | Utilisation of efficient reactions to combine moeities exhibiting biological activity to produce novel anti-infectives against HIV and malaria |
| title_full | Utilisation of efficient reactions to combine moeities exhibiting biological activity to produce novel anti-infectives against HIV and malaria |
| title_fullStr | Utilisation of efficient reactions to combine moeities exhibiting biological activity to produce novel anti-infectives against HIV and malaria |
| title_full_unstemmed | Utilisation of efficient reactions to combine moeities exhibiting biological activity to produce novel anti-infectives against HIV and malaria |
| title_short | Utilisation of efficient reactions to combine moeities exhibiting biological activity to produce novel anti-infectives against HIV and malaria |
| title_sort | utilisation of efficient reactions to combine moeities exhibiting biological activity to produce novel anti infectives against hiv and malaria |
| topic | Chemistry |
| url | http://hdl.handle.net/11427/6320 |
| work_keys_str_mv | AT kreinzeev utilisationofefficientreactionstocombinemoeitiesexhibitingbiologicalactivitytoproducenovelantiinfectivesagainsthivandmalaria |