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Utilization of the Baylis-Hillman and related reactions in antiparasitic drug discovery
Bibliography: leaves 81-83.
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
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Department of Chemistry
2014
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| _version_ | 1867613858727723009 |
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| access_status_str | Open Access |
| author | Mabizela, Nontobeko |
| author2 | Chibale, Kelly |
| author_browse | Chibale, Kelly Mabizela, Nontobeko |
| author_facet | Chibale, Kelly Mabizela, Nontobeko |
| author_sort | Mabizela, Nontobeko |
| collection | Thesis |
| description | Bibliography: leaves 81-83. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/6325 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:42:50.033Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Department of Chemistry |
| publisherStr | Department of Chemistry |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/6325 Utilization of the Baylis-Hillman and related reactions in antiparasitic drug discovery Mabizela, Nontobeko Chibale, Kelly Chemistry Bibliography: leaves 81-83. Baylis-Hillman adducts and compounds containing quinoline moieties have been previously utilized extensively in the search for antiparasitic agents. Work in this dissertation describes a series of compounds based on the Baylis-Hillman and the related three-component aza Baylis-Hillman reactions synthesised for biological evaluation as potential inhibitors of two parasitic cysteine proteases (cruzain and Falcipain-2) and as antiparasitic agents. The utilization of polymer-supported bases in the Baylis-Hillman reaction is described. The use of ultrasound in combination with Lewis acids is also described in an attempt to improve the reaction rate. 2014-08-13T14:26:54Z 2014-08-13T14:26:54Z 2003 Master Thesis Masters MSc http://hdl.handle.net/11427/6325 eng application/pdf Department of Chemistry Faculty of Science University of Cape Town |
| spellingShingle | Chemistry Mabizela, Nontobeko Utilization of the Baylis-Hillman and related reactions in antiparasitic drug discovery |
| thesis_degree_str | Master's |
| title | Utilization of the Baylis-Hillman and related reactions in antiparasitic drug discovery |
| title_full | Utilization of the Baylis-Hillman and related reactions in antiparasitic drug discovery |
| title_fullStr | Utilization of the Baylis-Hillman and related reactions in antiparasitic drug discovery |
| title_full_unstemmed | Utilization of the Baylis-Hillman and related reactions in antiparasitic drug discovery |
| title_short | Utilization of the Baylis-Hillman and related reactions in antiparasitic drug discovery |
| title_sort | utilization of the baylis hillman and related reactions in antiparasitic drug discovery |
| topic | Chemistry |
| url | http://hdl.handle.net/11427/6325 |
| work_keys_str_mv | AT mabizelanontobeko utilizationofthebaylishillmanandrelatedreactionsinantiparasiticdrugdiscovery |